EPHB4 and EFNB2

Number of citations: 105 (PubMedID 35384245)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		EPHB4	EFNB2
Name		EPH receptor B4	ephrin B2
Structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Plasma Membrane Adherens Junction Focal Adhesion Membrane Dendrite Presynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Virus Receptor Activity Signaling Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway	Angiogenesis Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation T Cell Costimulation Adherens Junction Organization Keratinocyte Proliferation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Venous Blood Vessel Morphogenesis Regulation Of Chemotaxis Cellular Response To Lipopolysaccharide Nephric Duct Morphogenesis Presynapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Aorta Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib	None
GWAS		Bipolar disorder ( 31043756 ) Blond vs. brown/black hair color ( 30531825 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 ) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020 ) Platelet distribution width ( 32888494 ) Resting heart rate ( 27798624 ) Takayasu arteritis ( 33308445 )	BMI x environmental factors (excluding physical activity) interaction ( 33654129 ) BMI x environmental factors (including physical activity) interaction ( 33654129 ) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676 ) Metabolite levels ( 23823483 ) Pediatric autoimmune diseases ( 26301688 ) Subcutaneous adipose tissue ( 26480920 )
Interacting Genes		7 interacting genes: APP DTX3 EFNB2 FBXO7 GRIN1 SDC3 VCP	23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC
Entrez ID		2050	1948
HPRD ID		02481	02754
Ensembl ID		ENSG00000196411	ENSG00000125266
Uniprot IDs		P54760 Q541P7 Q96L35	P52799
PDB IDs		2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM	2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Glutamate Receptor Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Synaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Response To Light Stimulus Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Biological Quality Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Metabolic Process Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Cell Adhesion Protein-containing Complex Lipoprotein Particle Extracellular Matrix Organization Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Extracellular Structure Organization Identical Protein Binding Negative Regulation Of Phosphate Transmembrane Transport Positive Regulation Of Wound Healing Establishment Of Endothelial Blood-brain Barrier Positive Regulation Of Aorta Morphogenesis Response To Glycine Propylene Metabolic Process Male Germ-line Sex Determination Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination EMILIN Complex	Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Dendrite Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Plasma Membrane Neuron Projection Organization Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Neuron Projection Cell Recognition Protein Tyrosine Kinase Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Postsynaptic Density Regulation Of Synaptic Transmission, Glutamatergic Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization Cell Migration Regulation Of Synapse Organization Regulation Of Cell Projection Organization Signal Transduction Synapse Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Cell Communication Postsynapse Organization Glutamatergic Synapse Regulation Of Signaling Neuron Projection Guidance Cell Motility Axon Guidance Postsynaptic Membrane Regulation Of Signal Transduction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Adhesion Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Nervous System Development G Protein-coupled Glutamate Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Response To Amyloid-beta