ADCK5 and HSPA6

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ADCK5	HSPA6
Name		aarF domain containing kinase 5	heat shock protein family A (Hsp70) member 6
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	None	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways		None	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
GWAS		Insomnia ( 27992416 )	Alanine aminotransferase levels ( 33547301 ) Birth weight ( 31043758 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173 ) Helicobacter pylori serologic status ( 23652523 ) Inflammatory bowel disease ( 23128233 28067908 ) Offspring birth weight ( 31043758 ) Ulcerative colitis ( 21297633 28067908 )
Interacting Genes		4 interacting genes: HSPA6 NOTCH2NLA RHOD TNS2	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1
Entrez ID		203054	3310
HPRD ID		12427	00775
Ensembl ID		ENSG00000173137	ENSG00000173110
Uniprot IDs		Q3MIX3	A0A384NKX5 B3KSM6 P17066
PDB IDs		Not available	3FE1
GO Terms Enriched among Interactors		None	Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization