ENO3 and PNKD

Number of citations: 0 (PubMedID 15188056)
Data Source: HPRD (two hybrid, in vitro)

		ENO3	PNKD
Name		enolase 3	PNKD metallo-beta-lactamase domain containing
Structure			No pdb structure
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Presynaptic Cytosol
	Molecular Function	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Metal Ion Binding	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Gluconeogenesis Glycolytic Process Canonical Glycolysis	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture
Pathways		Glycolysis Gluconeogenesis	None
Drugs		2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid	None
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Keratoconus ( 33649486 ) Red cell distribution width ( 32888494 )	Appendicular lean mass ( 33097823 ) Colorectal cancer ( 28960316 ) Colorectal cancer or advanced adenoma ( 30510241 ) Glycated hemoglobin levels ( 34059833 ) Granulocyte count ( 27863252 ) Height ( 28552196 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Hip circumference adjusted for BMI ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Inflammatory bowel disease ( 23128233 28067908 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Monocyte count ( 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Plateletcrit ( 32888494 27863252 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systolic blood pressure ( 30578418 ) Triglyceride levels ( 32203549 ) White blood cell count ( 27863252 )
Interacting Genes		20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN	7 interacting genes: APP ENO3 KCTD9 KLHL20 MAGEA11 MYL12B UBC
Entrez ID		2027	25953
HPRD ID		11746	11369
Ensembl ID		ENSG00000108515	ENSG00000127838
Uniprot IDs		P13929	Q8N490
PDB IDs		2XSX	Not available
GO Terms Enriched among Interactors		M Band I Band Titin-telethonin Complex Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Cytoplasm Somatic Muscle Development Myosin Filament Assembly Actin Cytoskeleton Supramolecular Fiber Organization Z Disc Structural Constituent Of Muscle Skeletal Muscle Thin Filament Assembly Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Detection Of Muscle Stretch Hexose Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Cardiac Muscle Tissue Morphogenesis Monosaccharide Metabolic Process Pyruvate Metabolic Process Muscle Contraction Muscle Tissue Morphogenesis Ribonucleoside Diphosphate Metabolic Process Neuron Projection Maintenance Contractile Muscle Fiber Titin Binding Purine Ribonucleotide Catabolic Process Axo-dendritic Transport Striated Muscle Contraction Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process System Process Cardiac Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Muscle System Process Actin Filament Organization Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Cardiac Muscle Hypertrophy Ficolin-1-rich Granule Lumen Response To Muscle Stretch Nucleoside Phosphate Catabolic Process Cytosol Muscle Hypertrophy	None