UNC13D and RAB27B

Number of citations: 0 (PubMedID 14699162)
Data Source: HPRD (in vitro)

		UNC13D	RAB27B
Name		unc-13 homolog D	RAB27B, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Recycling Endosome Exocytic Vesicle	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Granuloma Formation Germinal Center Formation Exocytosis Phagocytosis Regulation Of Mast Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Secretion Defense Response To Virus Establishment Of Localization In Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Neutrophil degranulation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Asthma ( 32296059 34103634 ) Eosinophil count ( 27863252 ) Major depressive disorder ( 27777418 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 30578418 ) White matter hyperintensity burden ( 25663218 )	Adult body size ( 32376654 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Body mass index ( 28892062 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 26604143 ) Depression ( 29700475 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )
Interacting Genes		3 interacting genes: LMNA RAB27A RAB27B	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		201294	5874
HPRD ID		10598	04846
Ensembl ID		ENSG00000092929	ENSG00000041353
Uniprot IDs		Q70J99	O00194
PDB IDs		Not available	2F7S
GO Terms Enriched among Interactors		Myosin V Binding Multivesicular Body Membrane Exocytic Vesicle Multivesicular Body Sorting Pathway GDP Binding G Protein Activity Positive Regulation Of Exocytosis Melanosome Secretory Granule Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Transport Late Endosome DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Regulation Of Exocytosis Establishment Of Protein Localization Exocytosis Protein Domain Specific Binding Complement-dependent Cytotoxicity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Establishment Of Organelle Localization Establishment Of Localization In Cell Exosomal Secretion Lamin Filament Nuclear Pore Localization Positive Regulation Of Secretion By Cell GTPase Activity Positive Regulation Of Secretion Weibel-Palade Body Platelet Dense Granule Membrane Intracellular Protein Localization Natural Killer Cell Degranulation Negative Regulation Of Mesenchymal Cell Proliferation Apical Plasma Membrane GTP Binding Secretion By Cell Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Organelle Localization Nuclear Lamina Protein Transport Along Microtubule Protein Localization To Nuclear Envelope Secretion Intracellular Protein Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Zymogen Granule Membrane	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel