UNC13D and RAB27A

Number of citations: 0 (PubMedID 14699162)
Data Source: BioGRID (pull down), HPRD (in vitro, in vivo)

		UNC13D	RAB27A
Name		unc-13 homolog D	RAB27A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Recycling Endosome Exocytic Vesicle	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Granuloma Formation Germinal Center Formation Exocytosis Phagocytosis Regulation Of Mast Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Secretion Defense Response To Virus Establishment Of Localization In Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Neutrophil degranulation	Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Apolipoprotein A1 levels ( 32203549 ) Asthma ( 32296059 34103634 ) Eosinophil count ( 27863252 ) Major depressive disorder ( 27777418 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 30578418 ) White matter hyperintensity burden ( 25663218 )	Fractional exhaled nitric oxide levels ( 25431337 ) Glioma ( 30714141 )
Interacting Genes		3 interacting genes: LMNA RAB27A RAB27B	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		201294	5873
HPRD ID		10598	04845
Ensembl ID		ENSG00000092929	ENSG00000069974
Uniprot IDs		Q70J99	A2RU94 P51159
PDB IDs		Not available	6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
GO Terms Enriched among Interactors		Myosin V Binding Multivesicular Body Membrane Exocytic Vesicle Multivesicular Body Sorting Pathway GDP Binding G Protein Activity Positive Regulation Of Exocytosis Melanosome Secretory Granule Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Transport Late Endosome DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Regulation Of Exocytosis Establishment Of Protein Localization Exocytosis Protein Domain Specific Binding Complement-dependent Cytotoxicity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Establishment Of Organelle Localization Establishment Of Localization In Cell Exosomal Secretion Lamin Filament Nuclear Pore Localization Positive Regulation Of Secretion By Cell GTPase Activity Positive Regulation Of Secretion Weibel-Palade Body Platelet Dense Granule Membrane Intracellular Protein Localization Natural Killer Cell Degranulation Negative Regulation Of Mesenchymal Cell Proliferation Apical Plasma Membrane GTP Binding Secretion By Cell Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Organelle Localization Nuclear Lamina Protein Transport Along Microtubule Protein Localization To Nuclear Envelope Secretion Intracellular Protein Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Zymogen Granule Membrane	Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region