ELANE and SERPIND1

Number of citations: 0 (PubMedID 2318847)
Data Source: HPRD (in vivo, in vitro)

		ELANE	SERPIND1
Name		elastase, neutrophil expressed	serpin family D member 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Chemotaxis Blood Coagulation Hemostasis
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid	Ardeparin Zinc Sulodexide Copper Bemiparin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Inherited thrombophilia
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	5 interacting genes: APP CFTR CTSG ELANE F2
Entrez ID		1991	3053
HPRD ID		00554	00795
Ensembl ID		ENSG00000197561	ENSG00000099937
Uniprot IDs		P08246	P05546 Q8IVC0
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU	1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV
GO Terms Enriched among Interactors		Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process	Neutrophil-mediated Killing Of Bacterium Neutrophil Mediated Immunity Heparin Binding Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Defense Response To Fungus Response To Fungus Neutrophil-mediated Killing Of Gram-negative Bacterium Leukocyte Mediated Cytotoxicity Immune Effector Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Receptor Ligand Activity Serine-type Peptidase Activity Killing Of Cells Of Another Organism Intracellular Chemical Homeostasis Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Response To Yeast Antimicrobial Humoral Response Cellular Homeostasis Cell Killing Defense Response To Symbiont Defense Response To Other Organism Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Protein Transport Humoral Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Defense Response To Bacterium Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Response To Other Organism Regulation Of Platelet Activation Negative Regulation Of Multicellular Organismal Process Cellular Response To CAMP Immune Response Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Antibacterial Humoral Response Response To Bacterium Acute Inflammatory Response Homeostatic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process