EIF2B1 and MRPL4

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		EIF2B1	MRPL4
Name		eukaryotic translation initiation factor 2B subunit alpha	mitochondrial ribosomal protein L4
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway	Translation Mitochondrial Translation
Pathways		Recycling of eIF2:GDP	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	None
GWAS		Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Alanine aminotransferase levels ( 33339817 ) Alanine transaminase levels ( 29403010 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Monocyte percentage of white cells ( 32888494 ) Pulse pressure ( 27841878 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	11 interacting genes: CLK2 CSNK2A1 DDX24 EIF2B1 ERCC6 EXOSC6 FILNC1 KRTAP4-12 RBFOX2 TRIM23 XRN2
Entrez ID		1967	51073
HPRD ID		09458	14759
Ensembl ID		ENSG00000111361	ENSG00000105364
Uniprot IDs		Q14232	Q9BYD3 X6RAY8
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMA 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQZ	3IY9 3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3
GO Terms Enriched among Interactors		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Regulation Of Smooth Muscle Contraction Norepinephrine Binding Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Catecholamine Secretion Translation Initiation Factor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Uterine Smooth Muscle Contraction Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Smooth Muscle Contraction ERBB Signaling Pathway Regulation Of Amine Transport Translational Initiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Vascular Process In Circulatory System Regulation Of Translational Initiation Circulatory System Process Cytoplasmic Translational Initiation Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Translation Initiation Ternary Complex Translation SUMO Conjugating Enzyme Activity Carbohydrate Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of Secretion Negative Regulation Of Peptide Secretion Macromolecule Biosynthetic Process Protein Metabolic Process	Double-strand Break Repair Via Classical Nonhomologous End Joining Nuclear-transcribed MRNA Catabolic Process Regulation Of DNA Recombination MRNA Catabolic Process RNA Metabolic Process Negative Regulation Of DNA Repair RNA Catabolic Process Negative Regulation Of Double-strand Break Repair MRNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of DNA Recombination Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Transcription Termination Site Sequence-specific DNA Binding