EEF2KMT and PRTFDC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		EEF2KMT	PRTFDC1
Description		eukaryotic elongation factor 2 lysine methyltransferase	phosphoribosyl transferase domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Protein-containing Complex	Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Peptidyl-lysine Trimethylation Methylation	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process
Pathways		Protein methylation
Drugs
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29617998) Lymphocyte count ( 27863252 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		12 interacting genes: HPRT1 IFT88 KIAA1328 LNX1 NR0B1 PICK1 PRKAR1B PRTFDC1 TRIP13 ZNF213 ZNF35 ZNF620	19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A
Entrez ID		196483	56952
HPRD ID		18018	17917
Ensembl ID		ENSG00000118894	ENSG00000099256
Uniprot IDs		K7ES84 Q96G04	Q9NRG1
PDB IDs		8FZB	2JBH
Enriched GO Terms of Interacting Partners?		Guanine Salvage Hypoxanthine Phosphoribosyltransferase Activity GMP Catabolic Process Guanine Metabolic Process Purine Ribonucleoside Salvage Purine Nucleobase Biosynthetic Process Nucleoside Salvage Purine Nucleoside Monophosphate Catabolic Process Purine Nucleobase Metabolic Process Purine Nucleoside Metabolic Process GMP Metabolic Process Purine-containing Compound Salvage Nucleoside Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Ciliary Base DNA Hairpin Binding Guanine Phosphoribosyltransferase Activity Nucleoside Monophosphate Metabolic Process Purine Ribonucleotide Catabolic Process Hypoxanthine Salvage Purine Nucleotide Catabolic Process Adenine Metabolic Process Hypoxanthine Biosynthetic Process Meiotic Recombination Checkpoint Signaling Nucleotide Catabolic Process AF-2 Domain Binding Hypoxanthine Metabolic Process Response To Silicon Dioxide Membrane Curvature Sensor Activity GMP Salvage Nucleoside Phosphate Catabolic Process IMP Salvage Centriolar Satellite Male Gamete Generation Spermatogenesis Positive Regulation Of Dopamine Metabolic Process AMP Salvage Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation CAMP-dependent Protein Kinase Regulator Activity Female Meiosis I Gamete Generation Metal Ion Binding Positive Regulation Of Fear Response Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Actin Nucleation
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