EGFR and GRB2

Number of citations: 105 (PubMedID 35384245)
Data Source: BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, protein complementation assay), HPRD (in vivo, in vitro)

		EGFR	GRB2
Name		epidermal growth factor receptor	growth factor receptor bound protein 2
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Nuclear Membrane Ruffle Membrane Protein-containing Complex Ciliary Basal Body Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Intracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell-cell Junction Cell Cortex COP9 Signalosome Vesicle Membrane Membrane Extracellular Exosome Grb2-EGFR Complex
	Molecular Function	Nucleotide Binding Virus Receptor Activity Chromatin Binding Double-stranded DNA Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Phosphatase Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Epidermal Growth Factor Binding Actin Filament Binding ATPase Binding	Phosphotyrosine Residue Binding RNA Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Insulin Receptor Substrate Binding Ephrin Receptor Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Ossification Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Hair Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Salivary Gland Morphogenesis Learning Or Memory Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Epidermis Development Cerebral Cortex Cell Migration Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation ERBB2-EGFR Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Protein Insertion Into Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Morphogenesis Of An Epithelial Fold Eyelid Development In Camera-type Eye Response To UV-A Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiocyte Differentiation	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Schwann Cell Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Endodermal Cell Differentiation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Myelination Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Insulin-like Growth Factor Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis B Cell Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Respiratory syncytial virus (RSV) attachment and entry Developmental Lineage of Mammary Gland Myoepithelial Cells	Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK
Drugs		Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Poziotinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib Mobocertinib Almonertinib Amivantamab	Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases		Laryngeal cancer Cervical cancer Oral cancer Gastric cancer Choriocarcinoma Esophageal cancer Glioma Bladder cancer	None
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Glioblastoma ( 28346443 29743610 ) Glioblastoma (age-stratified) ( 30152087 ) Glioma ( 21531791 28346443 29743610 ) Haemorrhoidal disease ( 33888516 ) Impulsivity ( 30718321 ) Initial alcohol sensitivity ( 30276832 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Non-glioblastoma glioma ( 28346443 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Refractive astigmatism ( 30306274 ) Subjective response to lithium treatment ( 26503763 )	Aspartate aminotransferase levels ( 33547301 ) Deep white matter hyperintensities ( 32517579 ) Multiple sclerosis ( 31604244 ) Systemic lupus erythematosus ( 26502338 28714469 29848360 ) Systemic sclerosis ( 31672989 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 )
Interacting Genes		412 interacting genes: ABL2 ACTA1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM AMH AMPH ANKS1A ANKS1B ANXA1 AOPEP APBA3 APBB1 APBB3 APP APPL1 AR AREG ARF4 ARHGEF12 ARHGEF7 ARRB2 ATP1A1 ATP1B1 ATP5F1C AXL B4GALT1 BAIAP2 BCAR3 BLK BLNK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CCDC88A CD44 CD82 CDC25A CDC34 CDH1 CDH5 CEACAM1 CEBPB CEND1 CLNK CLTA CLTCL1 CMTM8 CNOT9 CNTN2 COL9A3 CRK CSRP1 CTNNB1 CTNND1 CTTN CYLC2 DCBLD2 DCN DCTN2 DDX17 DEGS1 DIAPH1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP19 DUSP3 DYNC1H1 EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FANCC FAS FBXL2 FBXO25 FER FES FGR FKBP4 FKBP8 FN1 FNDC3B FRAT2 FRK GAB1 GABARAPL2 GAPDH GGA1 GGA3 GJB1 GNAI2 GNAS GOT1 GPM6B GPNMB GRAP2 GRB10 GRB14 GRB2 GRB7 GRIN2B GRK2 H3-4 HBEGF HCK HDAC7 HEMGN HEXIM1 HGS HOXC10 HPN HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 IKBKG IL13RA2 IL5RA ILKAP INPPL1 IQGAP1 IRS1 IRS4 ITGA5 ITGB1 ITGB2 ITK ITSN2 JAK2 JUP KCTD9P2 KEAP1 KRT17 KRT18 KRT7 KRT8 LAT LCK LCP2 LINC01139 LRP1 LRRK1 LYN MAP2K1 MAP3K12 MAP3K14 MAP3K3 MAP4K1 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 MAPT MAST1 MATR3 MDH1 MEGF6 MET MGARP MIF MOB4 MT-CO2 MTDH MUC1 MUC4 NANS NCAM1 NCK1 NCK2 NDN NEDD4 NF2 NHERF1 NIBAN2 NR3C1 NRG1 NTRK2 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRA PDGFRB PDK3 PDP1 PELI1 PFKP PIK3C2A PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PIM1 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPARG PPM1A PPM1B PPP2CB PPP3CB PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKCE PRKCZ PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN18 PTPN2 PTPN20 PTPN22 PTPN6 PTPN7 PTPRB PTPRH PTPRJ PTPRR PTPRS PTPRT PTPRU RAB31 RAB3A RAP1GDS1 RAPGEF1 RASA1 RGS16 RGS2 RGS4 RIMS2 RIN1 RIN2 RIPK1 RNF115 RNF126 RNF128 RNF130 RNF144A RNF167 RRAD RUSC2 S100A4 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SELENOP SFN SGSM2 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BGRL3 SH3GL3 SHB SHC1 SHC2 SHC3 SHC4 SHD SHE SLA SLA2 SLC3A2 SLC9D1 SMURF2 SNCA SNRPD2 SNX1 SNX2 SNX4 SNX6 SNX9 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAMBP STAP1 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B STIP1 STUB1 STX17 STYX SUPT6H SYK TAB1 TEC TGFA TGFB1 TJP1 TLN1 TLR2 TNC TNFRSF1A TNK2 TNS1 TNS2 TNS3 TNS4 TPI1 TPM1 TRAF2 TRMO TRPV1 TSTD2 TUBA1A TUBA4A TXK TXN UBB UBE2V2 UROD VAPA VAV1 VAV2 VAV3 WASF3 WASL XRCC6 YES1 YWHAB YWHAQ YWHAZ ZAP70 ZNF510 ZPR1	397 interacting genes: A2M ABI3 ABI3BP ABL1 ABL2 ACAP1 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AGR2 AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANKRD13A ANKRD23 ANXA2 AP4S1 APCS APOH APP AR ARHGAP17 ARHGAP32 ARHGAP35 ARID5A ASAP1 ASAP2 AUNIP AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM BTG1 C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCDC28B CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CEBPA CFH CHRM4 CHRND CKS2 CLNK CLU COPB1 COX6A1 CPSF7 CRBN CRK CRKL CSF1R CSF3R CSN2 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDIT4L DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 DTX3 DVL2 E2F2 ECHS1 EFHC2 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ESD ESR1 ETV6 FABP1 FASLG FCGR2A FCGR2B FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GC GGN GHR GIT1 GPANK1 GRAP2 GRB7 GSTK1 H1-0 H2AX HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA0408 KIAA1549L KIF3A KIT KPNA2 KPRP KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LNX2 LY6G6F LZTS2 MAP1A MAP2 MAP4K1 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED19 MED28 MEI4 MERTK MET METTL27 MIA2 MICAL1 MLXIPL MRE11 MS4A2 MSI2 MST1R MT-ATP8 MT-ND4 MTA1 MTA3 MUC1 MYG1 MYH11 MYO18A MYOZ1 NADK NAP1L5 NCKIPSD NCL NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL OLIG1 PACRGL PAG1 PAK1 PAK2 PAK4 PBXIP1 PCDHB5 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PHETA1 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHA7 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRR5-ARHGAP8 PRRC2A PRRG4 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RNF208 RPA1 RPS6KA1 SELL SF3A2 SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPATA2L SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TBC1D3B TBC1D3G TCEAL8 TCERG1 TEK TF TFG TLE5 TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIB3 TRIM27 TSC2 TSPAN2 TUB TXK UBA1 UBA52 UBC UQCC2 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM VPS37C WAS WASF1 WASF2 WASL WBP11 WDFY3 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB12 ZBTB7B ZMAT1 ZNF341 ZNF474 ZNF620
Entrez ID		1956	2885
HPRD ID		00579	00150
Ensembl ID		ENSG00000146648	ENSG00000177885
Uniprot IDs		B7Z2I3 C9JYS6 E7BSV0 F2YGG7 P00533 Q504U8	B0LPF3 P62993
PDB IDs		1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0 4LQM 4LRM 4R3P 4R3R 4R5S 4RIW 4RIX 4RIY 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8 4TKS 4UIP 4UV7 4WD5 4WKQ 4WRG 4ZAU 4ZJV 4ZSE 5C8K 5C8M 5C8N 5CAL 5CAN 5CAO 5CAP 5CAQ 5CAS 5CAU 5CAV 5CNN 5CNO 5CZH 5CZI 5D41 5EDP 5EDQ 5EDR 5EM5 5EM6 5EM7 5EM8 5FED 5FEE 5FEQ 5GMP 5GNK 5GTY 5GTZ 5HCX 5HCY 5HCZ 5HG5 5HG7 5HG8 5HG9 5HIB 5HIC 5J9Y 5J9Z 5JEB 5LV6 5SX4 5SX5 5U8L 5UG8 5UG9 5UGA 5UGB 5UGC 5UWD 5WB7 5WB8 5X26 5X27 5X28 5X2A 5X2C 5X2F 5X2K 5XDK 5XDL 5XGM 5XGN 5XWD 5Y25 5Y9T 5YU9 5ZTO 5ZWJ 6ARU 6B3S 6D8E 6DUK 6JRJ 6JRK 6JRX 6JWL 6JX0 6JX4 6JXT 6JZ0 6LUB 6LUD 6P1D 6P1L 6P8Q 6S89 6S8A 6S9B 6S9C 6S9D 6TFU 6TFV 6TFW 6TFY 6TFZ 6TG0 6TG1 6V5N 6V5P 6V66 6V6K 6V6O 6VH4 6VHN 6VHP 6WA2 6WAK 6WXN 6XL4 6Z4B 6Z4D 7A2A 7A6I 7A6J 7A6K 7AEI 7AEM 7B85 7ER2 7JXI 7JXK 7JXL 7JXM 7JXP 7JXQ 7JXW 7K1H 7K1I 7KXZ 7KY0 7LEN 7LFR 7LFS 7LG8 7LGS 7LTX 7OM4 7OXB 7SI1 7SYD 7SYE 7SZ0 7SZ1 7SZ5 7SZ7 7T4I 7T4J 7TVD 7U98 7U99 7U9A 7UKV 7UKW 7VRA 7VRE 7ZYM 7ZYN 7ZYP 7ZYQ 8A27 8A2A 8A2B 8A2D 8D73 8D76 8DSW 8EME 8F1H 8F1W 8F1X 8F1Y 8F1Z 8FV3 8FV4 8G63 8GB4 8GK5 8H7X 8HGO 8HGP 8HGS 8HV1 8HV2 8HV3 8HV4 8HV5 8HV6 8HV7 8HV8 8HV9 8HVA 8HY7 8KFQ 8PNZ 8PO0 8PO1 8PO2 8PO3 8PO4 8S1M 8SC7 8TJL 8TO3 8TO4 8UKV 8UKW 8UKX 8WD4 9D3V 9D3W 9EWS 9EWT 9FQP 9FQS 9FRD 9GC4 9GC5 9GC6 9GDV 9H46 9HBO	1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z 5CDW 6ICG 6ICH 6SDF 6VK2 6WM1 6WO2 7MPH 8DGO
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Phosphotyrosine Residue Binding Regulation Of Cell Communication Cytosol Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm ERBB Signaling Pathway Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Regulation Of Immune Response Regulation Of Immune System Process Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Regulation Of Transport Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cellular Component Organization Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Focal Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of MAPK Cascade Regulation Of Cell Adhesion Protein Kinase Activity ERBB2 Signaling Pathway Regulation Of Biological Quality Regulation Of Innate Immune Response Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Kinase Activity Regulation Of Apoptotic Process Activation Of Immune Response	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity SH3 Domain Binding Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Plasma Membrane Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade SH2 Domain Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Positive Regulation Of Cell Communication Regulation Of Immune Response Cytosol Protein Kinase Activity T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Binding Immune Response-activating Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Migration Activation Of Immune Response Response To Growth Factor