CELSR2 and KLF6

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		CELSR2	KLF6
Name		cadherin EGF LAG seven-pass G-type receptor 2	KLF transcription factor 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Adherens Junction Membrane	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cilium Movement Regulation Of DNA-templated Transcription Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Axonogenesis Anterior/posterior Pattern Specification Wnt Signaling Pathway Ventricular System Development Neural Plate Anterior/posterior Regionalization Regulation Of Cell-cell Adhesion Regulation Of Protein Localization Cerebrospinal Fluid Secretion Cell-cell Adhesion Mediated By Cadherin Animal Organ Development Dendrite Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Cilium Assembly Motor Neuron Migration Plasma Membrane Bounded Cell Projection Organization	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
GWAS		Abdominal aortic aneurysm ( 27899403 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cardiovascular disease risk factors ( 21943158 ) Cholesterol, total ( 19060911 20686565 28270201 26780889 25961943 24886709 ) Coronary artery disease ( 29212778 33020668 ) Coronary heart disease ( 21378988 ) HDL cholesterol ( 30275531 25961943 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heart failure ( 31919418 ) Heel bone mineral density ( 30598549 ) LDL cholesterol ( 30275531 18193043 26780889 20686565 20864672 19060911 19060910 21347282 19060906 18262040 18193044 25961943 18179892 ) LDL cholesterol levels ( 32203549 30698716 31087446 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Lipid metabolism phenotypes ( 19936222 ) Lipoprotein (a) levels ( 33730874 ) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643 ) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 ) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643 ) Low density lipoprotein cholesterol levels ( 30911093 33339817 29403010 32902719 32154731 30718733 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (antithrombotic agents) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 21909109 ) Myocardial infarction ( 33532862 ) Myocardial infarction (early onset) ( 19198609 ) Non-HDL cholesterol levels ( 32902719 ) Parental lifespan ( 30642433 ) Peripheral artery disease ( 31285632 ) Progranulin levels ( 21087763 29186428 ) Response to statin therapy ( 20339536 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Total cholesterol levels ( 30275531 32902719 29403010 30911093 33339817 30718733 )	Asthma (bronchodilator response) ( 23508266 ) Coronary artery calcification ( 23870195 ) Diastolic blood pressure ( 27841878 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 33713608 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 31604244 ) Plasma anti-thyroglobulin levels ( 29678681 ) Red blood cell count ( 32888494 )
Interacting Genes		3 interacting genes: GARS1 KLF6 PHF10	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		1952	1316
HPRD ID		05040	03632
Ensembl ID		ENSG00000143126	ENSG00000067082
Uniprot IDs		Q9HCU4	D3GC14 Q99612
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Diadenosine Tetraphosphate Biosynthetic Process DN4 Thymocyte Differentiation Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Chromatin Lymphocyte Differentiation Positive Regulation Of Artery Morphogenesis Mononuclear Cell Differentiation TRNA Aminoacylation For Mitochondrial Protein Translation Regulation Of Artery Morphogenesis Leukocyte Differentiation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive T Cell Selection RSC-type Complex NpBAF Complex Lymphocyte Activation Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Calcineurin-NFAT Signaling Cascade Leukocyte Activation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of MiRNA Transcription T Cell Selection Calcineurin-mediated Signaling Regulation Of Nucleotide-excision Repair SWI/SNF Complex Histone Acetyltransferase Activity	Pre-snoRNP Complex Histone Deacetylase Binding Nucleoplasm DNA Binding Box C/D Methylation Guide SnoRNP Complex RNA Metabolic Process Transcription Corepressor Binding Chromatin Remodeling Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Small-subunit Processome TFIID-class Transcription Factor Complex Binding Ribosomal Small Subunit Biogenesis DNA-templated Transcription Transcription Repressor Complex Box C/D SnoRNP Assembly P53 Binding Promoter-specific Chromatin Binding Regulation Of MiRNA Transcription Nucleus Chromatin Organization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II ATPase Binding RRNA Metabolic Process C2H2 Zinc Finger Domain Binding Cellular Response To Oxygen-containing Compound Low-density Lipoprotein Particle Nucleobase-containing Compound Biosynthetic Process Transcription Cis-regulatory Region Binding Histone Methyltransferase Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleolus Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Negative Regulation Of Transcription By RNA Polymerase II SnoRNA Binding Nucleic Acid Metabolic Process High-density Lipoprotein Particle RRNA Transcription Regulation Of RNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription