EFNB2 and EPHB6

Number of citations: 0 (PubMedID 10648835)
Data Source: HPRD (in vitro, in vivo)

		EFNB2	EPHB6
Name		ephrin B2	EPH receptor B6
Structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Focal Adhesion Membrane Dendrite Presynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation T Cell Costimulation Adherens Junction Organization Keratinocyte Proliferation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Venous Blood Vessel Morphogenesis Regulation Of Chemotaxis Cellular Response To Lipopolysaccharide Nephric Duct Morphogenesis Presynapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Aorta Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		None	Fostamatinib
GWAS		BMI x environmental factors (excluding physical activity) interaction ( 33654129 ) BMI x environmental factors (including physical activity) interaction ( 33654129 ) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676 ) Metabolite levels ( 23823483 ) Pediatric autoimmune diseases ( 26301688 ) Subcutaneous adipose tissue ( 26480920 )	Alcoholic chronic pancreatitis ( 28754779 ) Blood protein levels ( 30072576 ) Cancer ( 29299148 )
Interacting Genes		23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC	28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C
Entrez ID		1948	2051
HPRD ID		02754	04133
Ensembl ID		ENSG00000125266	ENSG00000106123
Uniprot IDs		P52799	A0A0G2JNH7 F8WCM8 O15197
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL	7K7J
GO Terms Enriched among Interactors		Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Dendrite Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Plasma Membrane Neuron Projection Organization Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Neuron Projection Cell Recognition Protein Tyrosine Kinase Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Postsynaptic Density Regulation Of Synaptic Transmission, Glutamatergic Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization Cell Migration Regulation Of Synapse Organization Regulation Of Cell Projection Organization Signal Transduction Synapse Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Cell Communication Postsynapse Organization Glutamatergic Synapse Regulation Of Signaling Neuron Projection Guidance Cell Motility Axon Guidance Postsynaptic Membrane Regulation Of Signal Transduction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Adhesion Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Nervous System Development G Protein-coupled Glutamate Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Response To Amyloid-beta	Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding