EDN1 and EDNRA

Number of citations: 0 (PubMedID 7509919)
Data Source: BioGRID (pull down), HPRD (in vivo)

		EDN1	EDNRA
Name		endothelin 1	endothelin receptor type A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Transport Vesicle Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding Receptor Ligand Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Histamine Secretion Response To Amphetamine Heart Process Glomerular Filtration Regulation Of Systemic Arterial Blood Pressure By Endothelin Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Regulation Of PH Smooth Muscle Contraction Mitochondrion Organization Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Dorsal/ventral Pattern Formation Response To Ozone Positive Regulation Of Heart Rate Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Thyroid Gland Development Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Embryonic Heart Tube Development Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Positive Regulation Of Canonical NF-kappaB Signal Transduction Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Cellular Response To Human Chorionic Gonadotropin Stimulus Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JNK Cascade Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Axon Extension Positive Regulation Of Calcium-mediated Signaling Cartilage Development Negative Regulation Of Protein Metabolic Process Membrane Depolarization Canonical Wnt Signaling Pathway Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Axonogenesis Involved In Innervation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Chemokine-mediated Signaling Pathway Renal Sodium Ion Absorption Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance Blood Vessel Diameter Maintenance CAMP/PKA Signal Transduction Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Salt Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Cation Channel Activity	Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Blood Vessel Remodeling Response To Amphetamine Regulation Of Heart Rate Heart Process Glomerular Filtration Cardiac Chamber Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Mitochondrion Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Response To Wounding Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Artery Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Neuron Remodeling Heparin Proteoglycan Metabolic Process Thyroid Gland Development Neuron Projection Development Glomerulus Development Cellular Response To Oxidative Stress Embryonic Heart Tube Development Aorta Development Vasoconstriction Norepinephrine Metabolic Process Middle Ear Morphogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Human Chorionic Gonadotropin Stimulus Developmental Pigmentation Enteric Nervous System Development Sympathetic Nervous System Development Axon Extension Embryonic Skeletal System Development Neuromuscular Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Head Development Face Development Axonogenesis Involved In Innervation Establishment Of Endothelial Barrier Pharyngeal Arch Artery Morphogenesis Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Protein Transmembrane Transport Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Renal Albumin Absorption Vascular Associated Smooth Muscle Cell Development Mesenchymal Cell Apoptotic Process Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance CAMP/PKA Signal Transduction Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Podocyte Apoptotic Process Meiotic Cell Cycle Process Involved In Oocyte Maturation Cranial Skeletal System Development Response To Acetylcholine Regulation Of Protein Localization To Cell Leading Edge Positive Regulation Of Cation Channel Activity
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		TBC-3711	Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
GWAS		Body mass index ( 26426971 ) Circulating vasoactive peptide levels ( 23381795 ) Coronary artery disease ( 29212778 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Multiple system atrophy ( 27629089 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 ) Pulse pressure ( 30224653 30578418 ) Red blood cell count ( 32888494 )	Carotid intima media thickness ( 21909108 ) Carotid plaque ( 30510157 ) Coronary artery disease ( 33020668 24262325 32469254 26343387 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary artery disease or large artery stroke ( 24262325 ) Dental caries ( 23064961 ) Intracranial aneurysm ( 22286173 ) Lead levels ( 26025379 ) Myocardial infarction ( 33532862 26343387 ) Obesity-related traits ( 23251661 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Peripheral artery disease ( 26488411 31285632 ) Plasma clusterin levels ( 26545630 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Resting heart rate ( 27798624 ) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171 ) Smoking initiation ( 33082346 ) Systolic blood pressure ( 27841878 )
Interacting Genes		10 interacting genes: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		1906	1909
HPRD ID		07030	00571
Ensembl ID		ENSG00000078401	ENSG00000151617
Uniprot IDs		P05305 Q6FH53	P25101
PDB IDs		1EDN 1EDP 1T7H 1V6R 5GLH 6DK5 8HCQ 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XVI 8XWP 8XWQ 8ZRT	8HCQ 8XVI 8XVJ 8XVK 8XVL
GO Terms Enriched among Interactors		Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Process In Circulatory System Endothelin Receptor Activity Circulatory System Process Protein Metabolic Process Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Substance P Catabolic Process Vasoconstriction Peptide Hormone Processing Regulation Of Blood Pressure Signaling Receptor Ligand Precursor Processing Sympathetic Neuron Axon Guidance Renal Albumin Absorption Protein Processing Peptidase Activity Hormone Metabolic Process Neuropeptide Catabolic Process Peptide Metabolic Process Regulation Of Hormone Levels Bradykinin Catabolic Process Renal Protein Absorption Regulation Of Blood Circulation Regulation Of Biological Quality Axonogenesis Involved In Innervation Vascular Associated Smooth Muscle Cell Development Endopeptidase Activity Angiotensin Maturation Proteolysis Metalloendopeptidase Activity Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Muscle Cell Development Protein Maturation Regulation Of Heart Rate Hormone Catabolic Process Developmental Pigmentation Vascular Associated Smooth Muscle Contraction Renal System Process Peptide Catabolic Process Metallopeptidase Activity Regulation Of Urine Volume System Process Renal Sodium Ion Absorption Embryonic Heart Tube Development Renal Sodium Ion Transport Macromolecule Metabolic Process Peptide Binding	Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Urine Volume Endothelin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Urine Volume Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Blood Pressure Regulation Of Secretion By Cell G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Secretion Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Contraction Regulation Of Cell Differentiation Regulation Of Hormone Secretion Positive Regulation Of Cell Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Secretion By Cell Positive Regulation Of Muscle Contraction Postsynaptic Signal Transduction Neural Crest Cell Migration Neutrophil Chemotaxis Positive Regulation Of Secretion Mesenchymal Cell Migration Smooth Muscle Contraction Positive Regulation Of Cell Cycle Regulation Of Smooth Muscle Contraction Regulation Of Interleukin-2 Production Regulation Of Vasoconstriction Neutrophil Migration