ECHS1 and ZNG1B

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ECHS1	ZNG1B
Name		enoyl-CoA hydratase, short chain 1	Zn regulated GTPase metalloprotein activator 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm
	Molecular Function	Catalytic Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Lyase Activity Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity	Nucleotide Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	None
Pathways		Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial short-chain enoyl-CoA hydratase deficiency 1	None
Drugs		Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids	None
GWAS		Lifespan ( 25918517 ) Nonunion in individuals with fractures ( 30680360 ) Serum metabolite levels ( 33031748 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: CAPN1 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 KAT2A LRRK1 LRRK2 PPM1B SERPINA1 SIRT3 UBA1 ZNG1B	1 interacting genes: ECHS1
Entrez ID		1892	150472
HPRD ID		03799	16687
Ensembl ID		ENSG00000127884	ENSG00000136682
Uniprot IDs		P30084	C9J3G2 Q8IUF1
PDB IDs		2HW5	Not available
GO Terms Enriched among Interactors		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Distribution Of Mitochondria Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Cytoplasmic Ribonucleoprotein Granule Mitochondrion Distribution Positive Regulation Of Canonical Wnt Signaling Pathway Translation Regulator Activity Neuron Projection Regulation Of Reactive Oxygen Species Metabolic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity GTP Binding Positive Regulation Of Wnt Signaling Pathway Identical Protein Binding Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Regulation Of Defense Response Regulation Of Synaptic Plasticity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Modulation Of Chemical Synaptic Transmission Peptide Glutaryltransferase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Mitochondrion Localization Regulation Of Cell Communication Small GTPase-mediated Signal Transduction Regulation Of Intracellular Signal Transduction GBD Domain Binding Storage Vacuole Regulation Of Signaling Regulation Of Defense Response To Virus JNK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H3K9 Acetyltransferase Activity Grb2-EGFR Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity	3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity 3-hydroxyacyl-CoA Dehydratase Activity Branched-chain Amino Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Oxidation Amino Acid Catabolic Process Isomerase Activity Lipid Modification Lyase Activity Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Catalytic Activity Mitochondrial Matrix Monocarboxylic Acid Metabolic Process