AGXT and ACAT1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AGXT	ACAT1
Name		alanine--glyoxylate aminotransferase	acetyl-CoA acetyltransferase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	L-serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Enzyme Binding Potassium Ion Binding Cholesterol O-acyltransferase Activity Identical Protein Binding Metal Ion Binding Coenzyme A Binding
	Biological Process	L-serine Metabolic Process Notch Signaling Pathway Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process L-alanine Catabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion	Liver Development Acetyl-CoA Biosynthetic Process L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Hormone Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import	Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle Beta-ketothiolase deficiency
Drugs		Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID	Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases		Primary hyperoxaluria (HP)	None
GWAS		Height ( 25282103 31562340 ) Urinary metabolites ( 26352407 )	Nonunion in individuals with fractures ( 30680360 ) Refractive error ( 32231278 )
Interacting Genes		39 interacting genes: ACAT1 ACTMAP ATXN1L BATF3 CFAP68 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19	4 interacting genes: AGXT PDP1 PEX7 PTPRF
Entrez ID		189	38
HPRD ID		05048	01946
Ensembl ID		ENSG00000172482	ENSG00000075239
Uniprot IDs		P21549	A0A140VJX1 A0A5F9ZHJ0 A0A5F9ZHL1 A0A5F9ZI66 P24752
PDB IDs		1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1 7NS7	2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Negative Regulation Of B Cell Receptor Signaling Pathway	Peroxisomal Matrix L-serine-pyruvate Transaminase Activity Peroxisome Matrix Targeting Signal-2 Binding Chondroitin Sulfate Proteoglycan Binding Protein Dephosphorylation C-X-C Motif Chemokine 12 Receptor Activity Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Glycine Biosynthetic Process, By Transamination Of Glyoxylate Peroxisome Oxalic Acid Secretion Dephosphorylation Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Phosphoprotein Phosphatase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Cell Migration Negative Regulation Of Receptor Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Carboxylic Acid Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Cell Motility Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Oxalate Transport Glyoxylate Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation Protein Targeting To Peroxisome Regulation Of Acyl-CoA Biosynthetic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process Ether Lipid Biosynthetic Process Glycine Metabolic Process Aldehyde Catabolic Process Amino Acid Binding L-serine Metabolic Process Protein Import Into Peroxisome Matrix Myelin Maintenance Cation Binding Transmembrane Receptor Protein Tyrosine Phosphatase Activity Dendritic Cell Chemotaxis