DSG1 and DSC2

Number of citations: 0 (PubMedID 9443898)
Data Source: HPRD (in vivo)

		DSG1	DSC2
Name		desmoglein 1	desmocollin 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Endoplasmic Reticulum Plasma Membrane Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy Cell-cell Adhesion	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of P38MAPK Cascade
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle	Keratinization Formation of the cornified envelope
Diseases		Striate palmoplantar keratoderma	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Eosinophilic esophagitis (pediatric) ( 20208534 ) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169 ) Yeast infection ( 28928442 )	Blood protein levels ( 30072576 ) Bronchopulmonary dysplasia ( 23897914 ) Metabolite levels ( 23823483 ) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738 )
Interacting Genes		8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3	6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3
Entrez ID		1828	1824
HPRD ID		00515	00512
Ensembl ID		ENSG00000134760	ENSG00000134755
Uniprot IDs		Q02413	A0A3B3ISU0 A0AAQ5BGT5 Q02487
PDB IDs		Not available	5ERP 5J5J 7A7D
GO Terms Enriched among Interactors		Desmosome Desmosome Organization Cornified Envelope Desmosome Assembly Cell-cell Junction Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Adherens Junction Alpha-catenin Binding Cell Junction Organization Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell Junction Assembly Cell-cell Junction Assembly Desmosome Maintenance Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell Adhesion Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Junction Cell-cell Junction Regulation Of Action Potential Homotypic Cell-cell Adhesion Intermediate Filament Binding Intermediate Filament Bundle Assembly Regulation Of Cardiac Muscle Contraction Cadherin Binding Regulation Of Striated Muscle Contraction Regulation Of Cell Adhesion Regulation Of Heart Rate Regulation Of Actin Filament-based Process Epithelial Cell-cell Adhesion Cell-cell Junction Maintenance Intermediate Filament Positive Regulation Of Cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Regulation Of Cell-substrate Adhesion Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Maintenance Ficolin-1-rich Granule Membrane Protein Localization To Membrane	Desmosome Cornified Envelope Desmosome Organization Cell-cell Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Assembly Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Cell Junction Cell Junction Organization Homotypic Cell-cell Adhesion Cell Adhesion Regulation Of Cardiac Muscle Contraction Cell Junction Assembly Gamma-catenin Binding Cell Adhesion Molecule Binding Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Epithelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Regulation Of Muscle Contraction Maternal Process Involved In Female Pregnancy Response To Progesterone Protein Localization To Plasma Membrane Adherens Junction Regulation Of Heart Contraction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cytoplasm Cellular Component Assembly Regulation Of System Process Protein Localization To Cell Periphery Calcium Ion Binding Regulation Of Muscle System Process Regulation Of Blood Circulation Purkinje Myocyte Development