DOCK1 and ELMO1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo, in vitro)

		DOCK1	ELMO1
Name		dedicator of cytokinesis 1	engulfment and cell motility 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Rac Protein Signal Transduction Actin Filament-based Process Actin Cytoskeleton Organization Cell Motility Regulation Of Postsynapse Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
GWAS		Airway wall thickness ( 25517131 ) Apolipoprotein Levels ( 23031429 ) Body mass index ( 25673413 ) Body mass index (change over time) in gastrointestinal cancer ( 28044437 ) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437 ) BRCA1/2-negative high-risk breast cancer ( 30323354 ) Chronotype ( 30696823 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367 ) Response to cytidine analogues (gemcitabine) ( 24483146 ) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627 ) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627 ) Social communication problems ( 24564958 ) Weight ( 28552196 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Anticoagulant levels ( 22216198 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Body fat mass ( 28552196 ) Breast size ( 22747683 ) Celiac disease ( 25920553 30572963 22057235 20190752 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Height ( 31562340 ) Inflammatory skin disease ( 25574825 ) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 27863252 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) PR interval ( 32439900 ) Primary biliary cirrhosis ( 22961000 ) Psoriasis ( 25574825 23143594 ) Psoriasis vulgaris ( 26626624 ) QT interval ( 20031603 ) Response to treatment for acute lymphoblastic leukemia ( 19176441 ) Rheumatoid arthritis ( 23143596 ) Sum eosinophil basophil counts ( 27863252 ) Systemic sclerosis ( 30572963 ) Trunk fat mass ( 28552196 ) Type 2 diabetes nephropathy ( 17653210 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2	11 interacting genes: ADGRB1 ADGRB3 APBB1 CEBPA DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		1793	9844
HPRD ID		03240	12102
Ensembl ID		ENSG00000150760	ENSG00000155849
Uniprot IDs		A0A096LNH6 A0A2X0U2H5 B2RUU3 Q14185	A4D1X5 Q92556
PDB IDs		3L4C	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC 7DPA 7Y4A 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
GO Terms Enriched among Interactors		SH3 Domain Binding Rac Protein Signal Transduction Actin Filament Organization Actin Cytoskeleton Organization Cell Chemotaxis Actin Filament-based Process Cell Motility Regulation Of Cellular Component Organization Supramolecular Fiber Organization Lamellipodium Assembly Regulation Of Postsynapse Assembly Lamellipodium Organization Chemotaxis Cell Migration Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Receptor Tyrosine Kinase Binding Positive Regulation Of Receptor Clustering Endocytosis Postsynapse Positive Regulation Of Protein Localization To Membrane Response To Hepatocyte Growth Factor Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Receptor Clustering Regulation Of Cytoskeleton Organization Actin Cytoskeleton Glutamatergic Synapse Regulation Of Bicellular Tight Junction Assembly Protein Kinase A Regulatory Subunit Binding Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Import Into Cell Regulation Of Cell Shape Regulation Of Postsynapse Organization Regulation Of Ruffle Assembly Cytosol Neuron Migration Phagocytosis, Engulfment Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Synapse Assembly Regulation Of Protein Localization To Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Supramolecular Fiber Organization	Myoblast Fusion Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Regulation Of Synapse Assembly Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Regulation Of Synapse Organization Phagocytosis Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Endocytosis Phagocytosis, Engulfment Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cellular Component Organization Regulation Of Postsynapse Assembly Postsynapse Membrane Invagination Regulation Of Cell Morphogenesis Import Into Cell Developmental Process GTPase Activator Activity Small GTPase-mediated Signal Transduction Cell Projection Positive Regulation Of Synapse Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Small GTPase Binding Actin Cytoskeleton Organization Cytoskeleton Response To Vitamin B2 C/EBP Complex Plasma Membrane Actin Filament-based Process Intracellular Signaling Cassette Cell Migration Regulation Of Developmental Process CHOP-C/EBP Complex Integrin-mediated Signaling Pathway Membrane Raft Polarization Regulation Of Phagocytosis Myeloid Dendritic Cell Activation Involved In Immune Response Leukocyte Migration Involved In Immune Response Positive Regulation Of Cell Junction Assembly Focal Adhesion White Fat Cell Proliferation Respiratory Burst After Phagocytosis Cell Recognition Regulation Of GTPase Activity Intracellular Signal Transduction