DLG3 and NLGN1

Number of citations: 0 (PubMedID 9278515)
Data Source: BioGRID (two hybrid)

		DLG3	NLGN1
Name		discs large MAGUK scaffold protein 3	neuroligin 1
Structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Golgi Apparatus Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Filopodium Tip Synaptic Cleft Dendritic Spine Receptor Complex Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Protein Complex Involved In Cell-cell Adhesion Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Protein Targeting Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Presynapse Assembly Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Neurexins and neuroligins Neurexins and neuroligins
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		Mean platelet volume ( 32888494 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Adverse response to drug ( 30420678 ) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Frailty index ( 34431594 ) Hand grip strength ( 29691431 ) Major depressive disorder ( 20516156 ) Metabolite levels ( 23823483 ) Motion sickness ( 25628336 ) Periodontitis (DPAL) ( 24024966 ) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Triglyceride levels ( 32154731 ) Triglyceride levels in HIV infection ( 33109212 ) Waist-to-hip ratio adjusted for BMI ( 28552196 ) Weight ( 28552196 )
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3
Entrez ID		1741	22871
HPRD ID		02177	07195
Ensembl ID		ENSG00000082458	ENSG00000169760
Uniprot IDs		Q59FY1 Q92796	A0A8Q3SHM6 Q8N2Q7
PDB IDs		1UM7 2FE5 2I1N	5OJ6 5OJK
GO Terms Enriched among Interactors		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Protein Localization To Cell Junction Vocalization Behavior Cell-cell Adhesion Receptor Localization To Synapse Social Behavior Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Neuron Cell-cell Adhesion Cell Adhesion Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Binding Learning Localization Within Membrane Cell-cell Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Communication Establishment Or Maintenance Of Apical/basal Cell Polarity Learning Or Memory Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Cognition Postsynaptic Membrane Assembly Synapse Vocal Learning Cell Adhesion Molecule Binding Postsynaptic Membrane Organization Observational Learning Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Presynaptic Membrane Cell Projection Mechanosensory Behavior Adult Behavior Establishment Or Maintenance Of Cell Polarity Glutamatergic Synapse