DHPS and EIF5A2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (two hybrid)

		DHPS	EIF5A2
Name		deoxyhypusine synthase	eukaryotic translation initiation factor 5A2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Protein Binding Transferase Activity Deoxyhypusine Synthase Activity Identical Protein Binding	RNA Binding Translation Elongation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Proliferation Glucose Homeostasis Spermidine Catabolic Process Protein Maturation	Translation Translational Elongation Spermatogenesis Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Hypusine synthesis from eIF5A-lysine	Hypusine synthesis from eIF5A-lysine
Drugs		1-Guanidinium-7-Aminoheptane	None
GWAS		Platelet distribution width ( 32888494 )	C-reactive protein levels ( 30388399 ) Urate levels ( 31578528 )
Interacting Genes		16 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 VASH1 ZNF138	10 interacting genes: CDC23 DHPS FNDC3B HERC3 HIF1A NIF3L1 PTBP2 RAB30 REL SDCBP
Entrez ID		1725	56648
HPRD ID		02969	10426
Ensembl ID		ENSG00000095059	ENSG00000163577
Uniprot IDs		P49366	Q9GZV4
PDB IDs		1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM 7A6S 7A6T 8A0E 8A0F 8A0G 8PVU 8R3U	Not available
GO Terms Enriched among Interactors		Regulation Of Translational Termination Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Elongation Translation Elongation Factor Activity Regulation Of Protein-containing Complex Disassembly Cytoplasm Positive Regulation Of Protein-containing Complex Disassembly Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein-N-terminal Glutamine Amidohydrolase Activity 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process	None