FAM9B and ABT1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM9B	ABT1
Name		family with sequence similarity 9 member B	activator of basal transcription 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm	Nucleus Transcription Regulator Complex Nucleolus
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding
	Biological Process	Spermatid Development Meiotic Cell Cycle	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spinal Cord Motor Neuron Differentiation Small-subunit Processome Assembly Positive Regulation Of DNA-templated Transcription
GWAS		Age at voice drop ( 27182965 ) Androgen levels ( 22936694 ) Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 29403010 ) Hemoglobin ( 29403010 ) Male-pattern baldness ( 27182965 29146897 ) Metabolite levels ( 23823483 )	A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) General cognitive ability ( 29844566 ) Hip circumference adjusted for BMI ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Left-handedness ( 32989287 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Refractive error ( 32231278 ) Small cell lung carcinoma ( 28604730 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference variance ( 31453325 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		140 interacting genes: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BAIAP2L2 BARD1 BCL2A1 BET1 BLOC1S2 BRME1 BYSL C8orf33 CADPS CCDC106 CCDC116 CCDC198 CCDC70 CDC23 CDC37 CDC42EP4 CDCA7L CDSN CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DGUOK DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G ELOA FAM161A FAM9A FASTKD3 FCHSD2 FERD3L FNDC11 GFOD1 GOPC GPX1 GRAMD4 GSTK1 HAPSTR1 HNRNPLL IBSP ISCU JAZF1 LBX1 LIN7A LINC02363 LMNA LNX1 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MRRF MYG1 MYO15B NDE1 NDUFB10 NEBL NOL4 NOTO PAGE1 PAGE3 PHYH PIN4 POLL PPARA PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RNF8 RPL9 RSL24D1 RUBCN RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMARCB1 SMN1 SMN2 SNAP29 SNAP47 SNX20 SRRM4 STK3 SUCLA2 SURF6 SYT17 TBC1D25 TBRG4 TCEA2 TCEANC TGFBI TOM1L2 TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 WT1 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614	16 interacting genes: APP CCDC136 CDCA7L CEP70 DVL3 EMD FAM9B LZTS2 MAB21L3 PICK1 PPP1CC PRNP RNF151 SYNE4 TBP TSPYL2
Entrez ID		171483	29777
HPRD ID		15955	16469
Ensembl ID		ENSG00000177138	ENSG00000146109
Uniprot IDs		Q8IZU0	Q9ULW3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Binding Mitochondrial Matrix RNA Binding	Neuron Projection Organization Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Lamin Binding Regulation Of Protein Localization Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Canonical Wnt Signaling Pathway Molecular Function Activator Activity Positive Regulation Of Receptor Internalization Amyloid Fibril Formation Response To Copper Ion Negative Regulation Of Wnt Signaling Pathway Frizzled Binding Nuclear Outer Membrane Negative Regulation Of Fibroblast Proliferation Dendritic Spine Organization Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Reproductive Process Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation TMEM240-body Male Gamete Generation Spermatogenesis Type 8 Metabotropic Glutamate Receptor Binding Postsynapse Organization Primary Ureteric Bud Growth Developmental Process Involved In Reproduction Cellular Response To Amyloid-beta Regulation Of Amyloid Precursor Protein Catabolic Process Postsynapse Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Receptor-mediated Endocytosis Cytoplasm Gamete Generation Regulation Of Canonical Wnt Signaling Pathway Response To Amyloid-beta Glial Cell Development Acetylcholine Receptor Activator Activity Positive Regulation Of Neuron Apoptotic Process Lipoprotein Particle