DFFB and TOP2A

Number of citations: 0 (PubMedID 10959840)
Data Source: BioGRID (pull down), HPRD (in vitro)

		DFFB	TOP2A
Name		DNA fragmentation factor subunit beta	DNA topoisomerase II alpha
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Protein-containing Complex	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding Nuclease Activity DNA Endonuclease Activity DNA Nuclease Activity Protein Binding Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Disordered Domain Specific Binding	Nucleotide Binding Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA DNA Binding, Bending Isomerase Activity Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Apoptotic Chromosome Condensation Negative Regulation Of Apoptotic DNA Fragmentation	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Metabolic Process DNA Topological Change Chromatin Organization DNA Damage Response Chromosome Segregation Female Meiotic Nuclear Division Chromosome Condensation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Apoptosis induced DNA fragmentation	Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins
Drugs		None	Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
GWAS		Blood trace element (Cu levels) ( 23720494 ) Metabolite levels ( 23823483 )	Appendicular lean mass ( 33097823 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 25673412 ) Neutrophil percentage of white cells ( 32888494 )
Interacting Genes		4 interacting genes: APP CIDEB DFFA TOP2A	36 interacting genes: ATM BRCA1 CDK1 CEBPA COPS5 CSNK2A1 DFFB DHX9 FBXO28 GINS1 HDAC1 HDAC2 HNRNPD JUN MAPK1 MDM4 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF10 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I USP7 XPO1 YWHAE
Entrez ID		1677	7153
HPRD ID		03532	00536
Ensembl ID		ENSG00000169598	ENSG00000131747
Uniprot IDs		B4DZS0 O76075 Q96P72 Q96P73 Q96P74	P11388
PDB IDs		1IBX	1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE 6ZY5 6ZY6 6ZY7 6ZY8 8W50
GO Terms Enriched among Interactors		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Apoptotic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Lipoprotein Particle Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apoptotic DNA Fragmentation Deoxyribonuclease Inhibitor Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Nuclease Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Apoptotic Chromosome Condensation Lipid Droplet Fusion Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition DNA Topoisomerase Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of RNA Biosynthetic Process Nucleoplasm Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of RNA Metabolic Process PML Body Regulation Of Cell Cycle DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of DNA Repair DNA Damage Checkpoint Signaling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Rhythmic Process Presynaptic Cytosol Regulation Of Protein Catabolic Process Postsynaptic Cytosol Regulation Of Proteolysis Mitotic Nuclear Membrane Disassembly Chromatin Organization Regulation Of Proteasomal Protein Catabolic Process