DDC and ATF6

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DDC	ATF6
Name		dopa decarboxylase	activating transcription factor 6
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Aromatic-L-amino-acid Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Enzyme Binding Pyridoxal Phosphate Binding 5-hydroxy-L-tryptophan Decarboxylase Activity L-dopa Decarboxylase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Kidney Development Amino Acid Metabolic Process Catecholamine Metabolic Process Response To Toxic Substance Gene Expression Carboxylic Acid Metabolic Process Biogenic Amine Biosynthetic Process Dopamine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response ERAD Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ATF6-mediated Unfolded Protein Response
Pathways		Catecholamine biosynthesis Serotonin and melatonin biosynthesis	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes
Drugs		Pyridoxal phosphate Carbidopa Methyldopa Benserazide	Pseudoephedrine
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603 22076464 23512250 ) Adult body size ( 32376654 ) Body mass index ( 25673413 26426971 ) Body mass index (age <50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Chronotype ( 30696823 ) Malaria ( 19465909 ) Morning person ( 30696823 ) Schizophrenia (treatment resistant) ( 25223841 ) Serum metabolite levels ( 33031748 )	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909 ) Parkinson's disease (age of onset) ( 19772629 ) Severe insulin-deficient type 2 diabetes ( 34737425 ) Systemic sclerosis ( 30247649 )
Interacting Genes		3 interacting genes: AR ATF6 RELA	18 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT RNF168 SRF TNFRSF1A UBASH3A XBP1 YY1
Entrez ID		1644	22926
HPRD ID		00145	16118
Ensembl ID		ENSG00000132437	ENSG00000118217
Uniprot IDs		A0A087WU57 A0A087WV24 A0A0S2Z3N4 P20711 Q53Y41	A0A7P0TAF2 A0A7P0Z421 A8K383 P18850
PDB IDs		3RBF 3RBL 3RCH 8OR9 8ORA	Not available
GO Terms Enriched among Interactors		Transcription Cis-regulatory Region Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Enzyme Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Transcription Coactivator Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Prostate Induction RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Male Somatic Sex Determination Positive Regulation Of ATF6-mediated Unfolded Protein Response Hormone-mediated Signaling Pathway Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis NF-kappaB P50/p65 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Male Genitalia Morphogenesis POU Domain Binding Negative Regulation Of Apoptotic Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Ketone Animal Organ Development Intracellular Receptor Signaling Pathway Response To Steroid Hormone Positive Regulation Of Integrin Biosynthetic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Cobalamin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Signal Transduction Androgen Binding Postsynapse To Nucleus Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication	Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process CCAAT-binding Factor Complex DNA Binding Regulation Of Gene Expression Protein-DNA Complex Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Peptide Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process ATF6-mediated Unfolded Protein Response Hemopoiesis Regulation Of Metabolic Process Myeloid Cell Development Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of MiRNA Transcription Response To Stress Nucleobase-containing Compound Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Stress Nucleoplasm Response To Unfolded Protein Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Regulation Of Cellular Response To Stress