| Name |
DCC netrin 1 receptor |
phosphatidylinositol transfer protein alpha |
| Structure |
|
|
| GO Annotations |
Cellular Component |
|
|
| Molecular Function |
|
|
| Biological Process |
|
|
| Pathways |
|
|
| Drugs |
None
|
|
| Diseases |
|
None
|
| GWAS |
- Age at first sexual intercourse ( 34211149
27089180
)
- Alcoholism (alcohol use disorder factor score) ( 21529783
)
- Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028
)
- Benign prostatic hyperplasia ( 30988330
)
- Body mass index ( 28892062
)
- Body mass index (ever vs never smoking interaction) ( 23192594
)
- Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148
)
- Brain morphology (MOSTest) ( 32665545
)
- Chronic back pain ( 30261039
)
- Coenzyme Q10 levels ( 27149984
)
- Cognitive ability ( 29186694
)
- Cognitive ability (MTAG) ( 29186694
)
- Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203
)
- Depression ( 27089181
29700475
33859377
)
- Experiencing mood swings ( 29500382
)
- Feeling fed-up ( 29500382
)
- Feeling miserable ( 29500382
)
- Gallbladder cancer ( 22318345
)
- Gastroesophageal reflux disease ( 34187846
)
- General cognitive ability ( 29844566
)
- General factor of neuroticism ( 30867560
)
- Glucose homeostasis traits ( 25524916
)
- Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821
)
- Homeostasis model assessment of insulin resistance ( 33381925
)
- Household income (MTAG) ( 31844048
)
- Intelligence (MTAG) ( 29326435
)
- Intraocular pressure ( 30591961
)
- Lung function (FVC) ( 30061609
30804560
)
- Mood instability ( 29187730
31168069
)
- Mosquito bite size ( 28199695
)
- Multisite chronic pain ( 33830993
31194737
)
- Neurociticism ( 29500382
)
- Nickel levels ( 26025379
)
- Number of sexual partners ( 30643258
)
- Obesity-related traits ( 23251661
)
- Putamen volume ( 29147026
)
- Response to exercise (triglyceride level interaction) ( 26491034
)
- Response to fenofibrate (total cholesterol levels) ( 27002377
)
- Response to mTOR inhibitor (everolimus) ( 24009623
)
- Risk-taking tendency (4-domain principal component model) ( 30643258
)
- Schizophrenia ( 33169155
30285260
)
- Short-term memory (digit-span task) ( 30741946
)
- Smoking behaviour (cigarettes smoked per day) ( 27393504
)
- Smoking initiation ( 33082346
)
- Smoking status (ever vs never smokers) ( 30643258
)
- Subcortical brain region volumes ( 25607358
)
- Survival in colorectal cancer (distant metastatic) ( 26586795
)
- White matter hyperintensity volume ( 33293549
)
- White matter hyperintensity volume (adjusted for hypertension) ( 33293549
)
- White matter hyperintensity volume x hypertension interaction (2df) ( 33293549
)
|
- Metabolite levels ( 23823483
)
- Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814
)
|
| Interacting Genes |
28 interacting genes:
ADORA2B
ALDOB
ANP32B
APPL1
AR
BARD1
CASP3
CASP9
CORO2A
CTSV
FBP1
HEMGN
MAPK3
MAZ
NCK1
NTN1
PITPNA
PTK2
RASA1
RPL5
SFRP2
SIAH1
SIAH2
TBC1D2
TDRD7
TMOD1
TRMO
TSTD2
|
9 interacting genes:
CSNK2B
DCC
EGFR
NEO1
PI4KA
PIK3C3
PLCG1
SCP2
UBC
|
| Entrez ID |
1630 |
5306 |
| HPRD ID |
00391
|
02548
|
| Ensembl ID |
ENSG00000187323
|
ENSG00000174238
|
| Uniprot IDs |
P43146
Q49AK4
|
B4E1U1
Q00169
V9HWC5
|
| PDB IDs |
2ED7
2ED8
2ED9
2EDB
2EDD
2EDE
3AU4
4URT
5X83
|
1UW5
8PQO
|
| GO Terms Enriched among Interactors |
|
|