SPRED1 and TTC19

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		SPRED1	TTC19
Name		sprouty related EVH1 domain containing 1	tetratricopeptide repeat domain 19
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Cytoplasmic Vesicle	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding
	Biological Process	Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Lens Fiber Cell Differentiation	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	Complex III assembly
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Bipolar disorder ( 20351715 ) Birth weight ( 31043758 ) Cognitive performance (processing speed) ( 31598132 ) Crohn's disease ( 23128233 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285 )	No GWAS studies recorded
Interacting Genes		40 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 DSCR9 DYRK1A FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RBM11 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655	44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688
Entrez ID		161742	54902
HPRD ID		11601	07899
Ensembl ID		ENSG00000166068	ENSG00000011295
Uniprot IDs		Q7Z699	Q6DKK2
PDB IDs		3SYX 6V65 6V6F	Not available