CYP2D6 and POR

Number of citations: 0 (PubMedID 15680923)
Data Source: BioGRID (pull down, pull down)

		CYP2D6	POR
Name		cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)	cytochrome p450 oxidoreductase
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Isoquinoline Alkaloid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Oxidative Demethylation Negative Regulation Of Organofluorine Metabolic Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process
Pathways		Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME	Cytochrome P450 - arranged by substrate type
Drugs		Cannabidiol Diacerein Nabiximols	Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases		None	46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Intelligence ( 28530673 ) Refractive error ( 32231278 ) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284 ) Schizophrenia ( 25056061 29483656 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Bitter beverage consumption ( 31046077 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Coffee consumption ( 25288136 31959922 31046077 ) Coffee consumption (cups per day) ( 31837886 25288136 ) Eosinophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31152163 31451708 ) High light scatter reticulocyte count ( 32888494 ) Low density lipoprotein cholesterol levels ( 32154731 ) Metabolite levels ( 23823483 ) Platelet count ( 32888494 ) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309 ) Reticulocyte count ( 32888494 ) Urinary albumin-to-creatinine ratio ( 31511532 )
Interacting Genes		3 interacting genes: CYB5A CYP2C9 POR	15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6
Entrez ID		1565	5447
HPRD ID		00487	00485
Ensembl ID		ENSG00000100197	ENSG00000127948
Uniprot IDs		C1ID52 P10635 Q5Y7H2	A0A9L9PY49 P16435
PDB IDs		2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD	1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
GO Terms Enriched among Interactors		Organofluorine Metabolic Process Intracellular Membrane-bounded Organelle Demethylation Heme Binding Xenobiotic Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Endoplasmic Reticulum Membrane (S)-limonene 7-monooxygenase Activity Arachidonate 11,12-epoxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Arachidonate 14,15-epoxygenase Activity Nitric Oxide Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Caffeine Oxidase Activity Fatty Acid Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Monoterpenoid Metabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Oxidative Demethylation Estrogen 2-hydroxylase Activity Enzyme Binding Positive Regulation Of Hormone Biosynthetic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Flavonoid Metabolic Process Carnitine Metabolic Process Monocarboxylic Acid Metabolic Process Urea Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Nitrogen Cycle Metabolic Process Epoxygenase P450 Pathway FMN Binding Steroid Hydroxylase Activity Oxidoreductase Activity Regulation Of Hormone Levels Response To Follicle-stimulating Hormone Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process	Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process