CYB5A and CYP1A2

Number of citations: 0 (PubMedID 15680923)
Data Source: BioGRID (pull down)

		CYB5A	CYP1A2
Name		cytochrome b5 type A	cytochrome P450 family 1 subfamily A member 2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	None	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Toxin Metabolic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Lung Development Methylation Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Aflatoxin Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidative Demethylation Cellular Response To Cadmium Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Isoniazid alpha-Naphthoflavone Cannabidiol Diacerein Nabiximols
Diseases		Methemoglobinemia	None
GWAS		Blood protein levels ( 30072576 )	Bladder cancer ( 25281661 ) Caffeine consumption ( 21490707 ) Coffee consumption ( 21357676 21876539 25288136 31959922 ) Coffee consumption (cups per day) ( 25288136 ) Diastolic blood pressure ( 19430483 ) Lung cancer ( 28604730 ) Mean arterial pressure ( 27618448 ) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102 ) Red blood cell count ( 27863252 32888494 ) Serum albumin levels ( 29403010 ) Urinary albumin excretion ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 )
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	3 interacting genes: ABHD16A CYB5A POR
Entrez ID		1528	1544
HPRD ID		08941	00489
Ensembl ID		ENSG00000166347	ENSG00000140505
Uniprot IDs		A0A384ME44 P00167	P05177
PDB IDs		2I96	2HI4
GO Terms Enriched among Interactors		Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process	Flavonoid Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Heme Binding Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Xenobiotic Metabolic Process Flavonoid 3'-monooxygenase Activity Lipid Modification Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Arachidonate Monooxygenase Activity Response To Nutrient Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Modified Amino Acid Metabolic Process Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Response To Ketone Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Positive Regulation Of Steroid Hormone Biosynthetic Process Monoacylglycerol Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Lipid Catabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Response To Phenylpropanoid