CYB5A and CYP1A1

Number of citations: 0 (PubMedID 6102994)
Data Source: HPRD (in vitro)

		CYB5A	CYP1A1
Name		cytochrome b5 type A	cytochrome P450 family 1 subfamily A member 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Catalytic Activity Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Monooxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Flavonoid 3'-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Metal Ion Binding Hsp90 Protein Binding Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	None	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Liver Development Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Nematode Response To Herbicide Response To Toxic Substance Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Genistein Response To Immobilization Stress Xenobiotic Catabolic Process Vitamin D Metabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Nitric Oxide Metabolic Process Response To Arsenic-containing Substance Digestive Tract Development Tissue Remodeling Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Diphenyl Ether Response To Aroclor 1254 Response To 2,3,7,8-tetrachlorodibenzodioxine Response To 3-methylcholanthrene
Pathways		Vitamin C (ascorbate) metabolism	PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	2-Methoxyestradiol Indirubin Nabiximols
Diseases		Methemoglobinemia	None
GWAS		Blood protein levels ( 30072576 )	Bitter beverage consumption ( 31046077 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Blood urea nitrogen levels ( 31152163 ) Caffeine consumption ( 21490707 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941 ) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Clozapine concentration in schizophrenia ( 32555152 ) Coffee consumption ( 21357676 31046077 21876539 25288136 ) Coffee consumption (cups per day) ( 31837886 25288136 ) Diastolic blood pressure ( 19430483 21909115 26390057 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Estimated glomerular filtration rate ( 31451708 31152163 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Microalbuminuria ( 31511532 ) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102 ) Platelet distribution width ( 27863252 ) Relative carbohydrate intake ( 32393786 ) Sweet beverage consumption ( 31046077 ) Systolic blood pressure ( 28739976 21909115 27618452 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Tea consumption ( 31046077 ) Urate levels ( 31578528 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31511532 31630189 30910378 ) Urinary potassium excretion ( 31409800 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	2 interacting genes: CMTM5 CYB5A
Entrez ID		1528	1543
HPRD ID		08941	00148
Ensembl ID		ENSG00000166347	ENSG00000140465
Uniprot IDs		A0A384ME44 P00167	A0N0X8 E7EMT5 P04798
PDB IDs		2I96	4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
GO Terms Enriched among Interactors		Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process	Aflatoxin Metabolic Process Electron Transfer Activity Toxin Metabolic Process Secondary Metabolic Process Toxin Biosynthetic Process Heme Binding Cellular Respiration Demethylase Activity Caffeine Oxidase Activity Dibenzo-p-dioxin Metabolic Process Synaptic Vesicle To Endosome Fusion Presynaptic Endosome Membrane NADP+ Binding Toxin Catabolic Process Aflatoxin Catabolic Process Hyaluronan Biosynthetic Process Positive Regulation Of Protein Kinase C Activity