SH3D19 and ADAM12

Number of citations: 0 (PubMedID 15280379)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		SH3D19	ADAM12
Name		SH3 domain containing 19	ADAM metallopeptidase domain 12
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways		Golgi Associated Vesicle Biogenesis	Signaling by EGFR Invadopodia formation
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Endometrial cancer ( 24096698 ) Extremely high intelligence ( 29731509 ) Heel bone mineral density ( 30598549 ) Intraocular pressure ( 30054594 ) Itch intensity from mosquito bite ( 28199695 ) Loneliness ( 27629369 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Mild influenza (H1N1) infection ( 26379185 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 26184070 ) Placental abruption ( 29884306 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Visceral fat ( 22589738 )
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
Entrez ID		152503	8038
HPRD ID		16364	04092
Ensembl ID		ENSG00000109686	ENSG00000148848
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	A8K6G4 O43184 Q5JRP2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	Intermediate Filament Keratin Filament Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Developmental Process Fibronectin Binding Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Phosphotyrosine Residue Binding T Cell Costimulation Insulin-like Growth Factor II Binding Protein Binding Cytosol Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Epidermis Development Hair Cycle Negative Regulation Of Cell-substrate Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Keratinization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of MAPK Cascade Angiotensin-activated Signaling Pathway Actin Filament Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway