SH3D19 and SOS2

Number of citations: 0 (PubMedID 14551139)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		SH3D19	SOS2
Name		SH3 domain containing 19	SOS Ras/Rho guanine nucleotide exchange factor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	B Cell Homeostasis Lymphocyte Homeostasis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Pro-B Cell Differentiation
Pathways		Golgi Associated Vesicle Biogenesis	NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle
GWAS		No GWAS studies recorded	Birth weight ( 31043758 ) Erythema nodosum in inflammatory bowel disease ( 24487271 ) Estimated glomerular filtration rate ( 31015462 ) Hemoglobin ( 32888494 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Pulse pressure ( 30578418 ) Red blood cell count ( 32888494 )
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	20 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL DSCAM EGFR GRAP2 GRB2 HRAS ITSN1 ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9 UBASH3A
Entrez ID		152503	6655
HPRD ID		16364	03149
Ensembl ID		ENSG00000109686	ENSG00000100485
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	Q07890
PDB IDs		Not available	6EIE 8T5G 8T5M 8T5R 8UC9 8UF2 8UH0 9BVE 9BVF 9BVI 9GIN
GO Terms Enriched among Interactors		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cellular Component Organization Plasma Membrane Tubulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Plasma Membrane Intracellular Signal Transduction Response To Growth Factor Cytosol Proline-rich Region Binding Lipid Tube Assembly Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Vesicle Regulation Of Actin Cytoskeleton Organization Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding MAPK Cascade Regulation Of MAPK Cascade Regulation Of Immune Response Ruffle Positive Regulation Of Immune Response Cytoplasm Epidermal Growth Factor Binding Small GTPase-mediated Signal Transduction Synaptic Vesicle Endocytosis Cellular Response To Growth Factor Stimulus Endosome Regulation Of ERK1 And ERK2 Cascade Presynaptic Endocytosis Positive Regulation Of Cellular Component Biogenesis