SH3D19 and SH3YL1

Number of citations: 0 (PubMedID 12615363)
Data Source: HPRD (in vitro)

		SH3D19	SH3YL1
Name		SH3 domain containing 19	SH3 and SYLF domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Ruffle Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Protein Binding Phosphatase Binding Phosphatidylinositol Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Phosphatidylinositol Biosynthetic Process Regulation Of Ruffle Assembly
Pathways		Golgi Associated Vesicle Biogenesis	None
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Apolipoprotein A1 levels ( 32203549 ) Blood urea nitrogen levels ( 31152163 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Large artery stroke ( 28265093 ) Mitochondrial DNA levels ( 25240745 ) Night sleep phenotypes ( 27126917 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	11 interacting genes: AR ERRFI1 GFAP HELZ KHDRBS1 PRB3 SH3D19 SYNJ1 VIM VPS37B ZBTB7B
Entrez ID		152503	26751
HPRD ID		16364	15336
Ensembl ID		ENSG00000109686	ENSG00000035115
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	Q96HL8
PDB IDs		Not available	2D8H
GO Terms Enriched among Interactors		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	Bergmann Glial Cell Differentiation Astrocyte Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Gene Expression Cellular Response To Steroid Hormone Stimulus Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Schwann Cell Proliferation Astrocyte Differentiation Kinase Binding Intermediate Filament Organization Schwann Cell Proliferation Glial Cell Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Synaptic Vesicle Uncoating Positive Regulation Of Endosome Organization Grb2-Sos Complex Negative Regulation Of NK T Cell Activation Negative Regulation Of NK T Cell Proliferation Positive Regulation Of SREBP Signaling Pathway Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Positive Regulation Of Viral Budding Via Host ESCRT Complex Male Genitalia Morphogenesis POU Domain Binding Glial Cell Differentiation Phosphatidylinositol Phosphate 4-phosphatase Activity SH3 Domain Binding NK T Cell Differentiation Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Cellular Response To Lipid Negative Regulation Of Neuron Projection Development