KLC3 and CROCC

Number of citations: 27 (PubMedID 12427867)
Data Source: HPRD (two hybrid)

		KLC3	CROCC
Name		kinesin light chain 3	ciliary rootlet coiled-coil, rootletin
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytoskeleton Kinesin Complex Microtubule Motile Cilium Ciliary Rootlet Neuron Projection	Photoreceptor Inner Segment Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Actin Cytoskeleton Ciliary Rootlet Ciliary Basal Body Cell Projection Extracellular Exosome Glial Cell Projection 9+2 Motile Cilium Subapical Part Of Cell
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Kinesin Binding
	Biological Process	Microtubule-based Movement Spermatogenesis Spermatid Development Axo-dendritic Transport Cell Differentiation Sperm Mitochondrial Sheath Assembly	Centrosome Cycle Intracellular Protein Localization Centriole-centriole Cohesion Epithelial Structure Maintenance Cellular Homeostasis Cell Projection Organization Ciliary Basal Body Organization Protein Localization To Organelle Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Establishment Of Localization In Cell Establishment Of Organelle Localization Positive Regulation Of Protein Localization To Cilium
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	None
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 )	Allergic rhinitis ( 22036096 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Hematocrit ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Red blood cell count ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 28552196 34021172 ) Waist-hip index ( 34021172 )
Interacting Genes		41 interacting genes: ABI3 ATP23 BBS5 BICDL2 CBY2 CCNH CENPP CEP57L1 CROCC CT55 DTX2 GEM IHO1 IMP3 KDM1A KIF5A KIF5B KIF5C KLHL21 KRT13 KRT15 MBIP NDC80 NECAB2 NEFL PCBD2 PDE4DIP QARS1 SMARCB1 SNAP47 STX11 TCF4 USHBP1 VPS52 WAC WASHC1 YWHAG YWHAH YWHAQ ZNF417 ZNF572	2 interacting genes: KLC3 RNF152
Entrez ID		147700	9696
HPRD ID		03212	16758
Ensembl ID		ENSG00000104892	ENSG00000058453
Uniprot IDs		Q6P597	Q5TZA2
PDB IDs		Not available	6L5H 6L5J
GO Terms Enriched among Interactors		Ciliary Rootlet Organelle Localization Establishment Of Organelle Localization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Anterograde Axonal Transport Establishment Of Vesicle Localization Identical Protein Binding Dendritic Transport Vesicle Localization Plus-end-directed Microtubule Motor Activity Axon Cytoplasm Retrograde Axonal Transport Axonal Transport Dendrite Cytoplasm Axo-dendritic Transport Postsynaptic Cytosol Protein Binding Retrograde Neuronal Dense Core Vesicle Transport Transport Along Microtubule Organelle Transport Along Microtubule Synaptic Vesicle Transport Cytoskeleton-dependent Intracellular Transport Cytoskeleton Vesicle Transport Along Microtubule Kinesin Complex Microtubule-based Transport Establishment Of Localization In Cell Dense Core Granule Cytoskeletal Transport Receptor Localization To Synapse Presynapse Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cytosolic Transport Vesicle Fusion To Plasma Membrane Vesicle Cytoskeletal Trafficking Microtubule Binding Microtubule Motor Activity Intracellular Transport Protein Localization To Synapse Microtubule-based Process Synaptic Vesicle Membrane Organization Intracellular Protein Localization Insulin-like Growth Factor Receptor Binding Establishment Of Protein Localization Intermediate Filament Organization Secretory Granule Localization Protein Localization To Cell Junction Intermediate Filament Cytoskeleton Organization	None