FBXL16 and MAPK6

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FBXL16	MAPK6
Name		F-box and leucine rich repeat protein 16	mitogen-activated protein kinase 6
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	MAPK6/MAPK4 signaling
Drugs		None	Acetylsalicylic acid Minocycline Colforsin
GWAS		Attention deficit hyperactivity disorder ( 29325848 ) Smoking status (ever vs never smokers) ( 30643258 ) Waist circumference adjusted for body mass index ( 34021172 )	Frailty index ( 34431594 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )
Interacting Genes		3 interacting genes: DSCR9 HIF1A MAPK6	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		146330	5597
HPRD ID		12365	04213
Ensembl ID		ENSG00000127585	ENSG00000069956
Uniprot IDs		Q8N461	Q16659
PDB IDs		Not available	6YKY 6YLC 6YLL 7AQB
GO Terms Enriched among Interactors		Elastin Metabolic Process Glandular Epithelial Cell Maturation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway DNA-binding Transcription Repressor Activity Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Mesenchymal Cell Apoptotic Process Iris Morphogenesis Columnar/cuboidal Epithelial Cell Maturation Regulation Of Thymocyte Apoptotic Process Hemoglobin Biosynthetic Process Vascular Endothelial Growth Factor Production Intracellular Oxygen Homeostasis Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus B-1 B Cell Homeostasis Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Axonal Transport Of Mitochondrion Hemoglobin Metabolic Process Transcription Regulator Activator Activity Neural Fold Elevation Formation Intestinal Epithelial Cell Maturation Protein Kinase Binding Protein Heterodimerization Activity Positive Regulation Of Hormone Biosynthetic Process Connective Tissue Replacement Negative Regulation Of Thymocyte Apoptotic Process Retina Vasculature Development In Camera-type Eye Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Chemokine-mediated Signaling Pathway Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Septin Cytoskeleton MAP Kinase Activity Lactate Metabolic Process Mammary Gland Epithelial Cell Differentiation Response To Iron Ion Negative Regulation Of T Cell Apoptotic Process Embryonic Hemopoiesis Negative Regulation Of MiRNA Transcription Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dopaminergic Neuron Differentiation Epithelial Cell Maturation Glandular Epithelial Cell Differentiation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Hormone Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Production B Cell Homeostasis Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Response To Muscle Activity	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding