CSF1 and GAB3

Number of citations: 52 (PubMedID 11739737)
Data Source: HPRD (in vivo)

		CSF1	GAB3
Name		colony stimulating factor 1	GRB2 associated binding protein 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex	Cytoplasm
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity	Signaling Adaptor Activity
	Biological Process	Neutrophil Homeostasis Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Immune System Process Positive Regulation Of Leukocyte Migration Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Monocyte Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Mononuclear Cell Proliferation Monocyte Homeostasis Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Macrophage Homeostasis Myeloid Leukocyte Migration Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration	Signal Transduction Macrophage Differentiation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity	Signaling by CSF1 (M-CSF) in myeloid cells
GWAS		Adult onset Still's disease ( 32149159 ) Aspartate aminotransferase levels ( 33547301 33339817 29403010 ) Blood protein levels in cardiovascular risk ( 28369058 ) Creatine kinase levels ( 29403010 ) Cryptococcosis in HIV infection ( 33269293 ) Height ( 31562340 ) High density lipoprotein cholesterol levels ( 33339817 ) Lactate dehydrogenase levels ( 29403010 ) Lymphocyte count ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Paget's disease ( 21623375 20436471 ) Periventricular white matter hyperintensities ( 32517579 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954 ) Serum total protein levels ( 29403010 ) Total body bone mineral density ( 29304378 ) White blood cell count ( 32888494 27863252 )	Glycated hemoglobin levels ( 34059833 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 28453575 ) Mean spheric corpuscular volume ( 32888494 )
Interacting Genes		13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF	8 interacting genes: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC
Entrez ID		1435	139716
HPRD ID		00388	06571
Ensembl ID		ENSG00000184371	ENSG00000160219
Uniprot IDs		P09603	Q8WWW8
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF	Not available
GO Terms Enriched among Interactors		Macrophage Differentiation Myeloid Leukocyte Differentiation Response To Macrophage Colony-stimulating Factor Myeloid Cell Differentiation Leukocyte Differentiation	T Cell Costimulation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Activation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of Cell Adhesion Immune Effector Process Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Regulation Of Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Defense Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Immune System Process Cell Motility Regulation Of Lymphocyte Activation Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Localization Negative Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling