TMEM37 and SPIB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TMEM37	SPIB
Name		transmembrane protein 37	Spi-B transcription factor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Monoatomic Ion Channel Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	Voltage-gated Monoatomic Ion Channel Activity Calcium Channel Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport	Immature B Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II
GWAS		No GWAS studies recorded	Primary biliary cholangitis ( 20639880 21399635 26394269 ) Systolic blood pressure ( 30224653 )
Interacting Genes		6 interacting genes: HBP1 MPP3 ORM1 PLA2G12A SPIB UBQLN1	19 interacting genes: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37
Entrez ID		140738	6689
HPRD ID		15536	06007
Ensembl ID		ENSG00000171227	ENSG00000269404
Uniprot IDs		E7EMC0 Q86SV2 Q8WXS4	Q01892
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Transcription Regulator Complex Chromatin Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleoplasm RNA Polymerase II Transcription Regulator Complex Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Apoptotic Process DNA-binding Transcription Activator Activity Rb-E2F Complex DNA-binding Transcription Factor Activity Cell Death Programmed Cell Death RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Myeloid Cell Differentiation DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding Sequence-specific DNA Binding Chromatin Binding Negative Regulation Of Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of Apoptotic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific