TMEM37 and ORM1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TMEM37	ORM1
Name		transmembrane protein 37	orosomucoid 1
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane Monoatomic Ion Channel Complex	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Voltage-gated Monoatomic Ion Channel Activity Calcium Channel Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport	Regulation Of Immune System Process Acute-phase Response Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production
Pathways		None	Platelet degranulation Neutrophil degranulation
Drugs		None	Amsacrine Lidocaine Progesterone Chlorpromazine Dipyridamole Thalidomide
GWAS		No GWAS studies recorded	End-stage coagulation ( 23381943 ) Thrombin generation potential phenotypes ( 24357727 ) Tourette syndrome ( 22889924 )
Interacting Genes		6 interacting genes: HBP1 MPP3 ORM1 PLA2G12A SPIB UBQLN1	9 interacting genes: ALB BLVRB CCR5 GLUD1 GSDMB PIK3R3 SERPINE1 TMEM37 TP63
Entrez ID		140738	5004
HPRD ID		15536	00724
Ensembl ID		ENSG00000171227	ENSG00000229314
Uniprot IDs		E7EMC0 Q86SV2 Q8WXS4	P02763
PDB IDs		Not available	3KQ0
GO Terms Enriched among Interactors		None	Platelet Alpha Granule Lumen Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Biliverdin Reductase [NAD(P)H] Activity Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity Insulin Receptor Signaling Pathway FMN Reductase (NADH) Activity Chemokine (C-C Motif) Ligand 5 Binding Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Defense Response To Gram-negative Bacterium Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Cytotoxic T Cell Pyroptotic Cell Death Odontogenesis Peptidyl-cysteine S-nitrosylase Activity Negative Regulation Of Integrin-mediated Signaling Pathway Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Regulation Of Smooth Muscle Cell-matrix Adhesion Peptidase Inhibitor Complex Prostatic Bud Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Negative Regulation Of Mitochondrial Depolarization Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Calcium Ion Transmembrane Transport Negative Regulation Of Macrophage Apoptotic Process L-leucine Binding Glutamate Biosynthetic Process L-glutamate Catabolic Process Positive Regulation Of Odontoblast Differentiation Dentinogenesis Negative Regulation Of Vascular Wound Healing Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Plasminogen Activation