HAPLN1 and MMP2

Number of citations: 30 (PubMedID 7694569)
Data Source: HPRD (in vitro)

		HAPLN1	MMP2
Name		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Synapse Perineuronal Net	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Hyaluronic acid	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases		None	Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Ankylosing spondylitis ( 22138694 ) Blood protein levels ( 30072576 ) Carotid intima media thickness (mean) ( 31801372 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) Metabolite levels ( 23823483 ) Prostate cancer ( 17903305 ) Visceral fat ( 22589738 ) Waist circumference ( 28552196 ) White matter integrity (fractional anisotropy) ( 29752348 ) White matter integrity (mean diffusivity) ( 29752348 )	Heel bone mineral density ( 30598549 ) Lack of premeditation ( 30718321 ) Refractive error ( 32231278 )
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		1404	4313
HPRD ID		00275	00386
Ensembl ID		ENSG00000145681	ENSG00000087245
Uniprot IDs		P10915	P08253
PDB IDs		Not available	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
GO Terms Enriched among Interactors		Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Endopeptidase Activity Metalloendopeptidase Activity Metallopeptidase Activity Extracellular Space Serine-type Endopeptidase Activity Cellular Response To UV-A Response To Amyloid-beta Response To UV-A Extracellular Region Peptidase Activity Proteolysis Cellular Response To UV Response To Light Stimulus Perineuronal Net Golgi Lumen Cellular Response To Light Stimulus Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein Metabolic Process Regulation Of Cell Migration Response To Radiation Central Nervous System Development Regulation Of Cell Motility Response To UV Regulation Of Locomotion Hyaluronic Acid Binding Cellular Response To Radiation Skeletal System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Ephrin Receptor Signaling Pathway Hydrolase Activity Cellular Response To Oxygen-containing Compound Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis