HAPLN1 and ACAN

Number of citations: 0 (PubMedID 12888576)
Data Source: HPRD (in vitro)

		HAPLN1	ACAN
Name		hyaluronan and proteoglycan link protein 1	aggrecan
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Synapse Perineuronal Net	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development
Pathways		ECM proteoglycans	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Hyaluronic acid	Ilomastat
Diseases		None	Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type
GWAS		Ankylosing spondylitis ( 22138694 ) Blood protein levels ( 30072576 ) Carotid intima media thickness (mean) ( 31801372 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) Metabolite levels ( 23823483 ) Prostate cancer ( 17903305 ) Visceral fat ( 22589738 ) Waist circumference ( 28552196 ) White matter integrity (fractional anisotropy) ( 29752348 ) White matter integrity (mean diffusivity) ( 29752348 )	Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR
Entrez ID		1404	176
HPRD ID		00275	01123
Ensembl ID		ENSG00000145681	ENSG00000157766
Uniprot IDs		P10915	A0A5K1VW97 P16112
PDB IDs		Not available	4MD4 7RDV
GO Terms Enriched among Interactors		Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Endopeptidase Activity Metalloendopeptidase Activity Metallopeptidase Activity Extracellular Space Serine-type Endopeptidase Activity Cellular Response To UV-A Response To Amyloid-beta Response To UV-A Extracellular Region Peptidase Activity Proteolysis Cellular Response To UV Response To Light Stimulus Perineuronal Net Golgi Lumen Cellular Response To Light Stimulus Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein Metabolic Process Regulation Of Cell Migration Response To Radiation Central Nervous System Development Regulation Of Cell Motility Response To UV Regulation Of Locomotion Hyaluronic Acid Binding Cellular Response To Radiation Skeletal System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Ephrin Receptor Signaling Pathway Hydrolase Activity Cellular Response To Oxygen-containing Compound Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding	Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion