HAPLN1 and VCAN

Number of citations: 0 (PubMedID 12888576)
Data Source: HPRD (in vitro)

		HAPLN1	VCAN
Name		hyaluronan and proteoglycan link protein 1	versican
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Synapse Perineuronal Net	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Cell Projection Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Protein Tyrosine Phosphatase Activator Activity Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Skeletal System Development Osteoblast Differentiation Cell Adhesion Central Nervous System Development Cell Recognition Glial Cell Migration System Development
Pathways		ECM proteoglycans	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs		Hyaluronic acid	Hyaluronic acid
Diseases		None	Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Ankylosing spondylitis ( 22138694 ) Blood protein levels ( 30072576 ) Carotid intima media thickness (mean) ( 31801372 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) Metabolite levels ( 23823483 ) Prostate cancer ( 17903305 ) Visceral fat ( 22589738 ) Waist circumference ( 28552196 ) White matter integrity (fractional anisotropy) ( 29752348 ) White matter integrity (mean diffusivity) ( 29752348 )	Appendicular lean mass ( 33097823 28724990 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Carotid intima media thickness (mean) ( 31801372 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical volume ( 32963231 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol levels ( 32203549 ) Joint mobility (Beighton score) ( 27182965 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lean body mass ( 28724990 ) Major depressive disorder ( 20516156 ) Optic disc size ( 31809533 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter hyperintensity volume ( 29752348 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter integrity (fractional anisotropy) ( 29752348 32358547 ) White matter integrity (mean diffusivity) ( 29752348 32358547 )
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		1404	1462
HPRD ID		00275	00340
Ensembl ID		ENSG00000145681	ENSG00000038427
Uniprot IDs		P10915	P13611 Q59FG9 Q86W61
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Endopeptidase Activity Metalloendopeptidase Activity Metallopeptidase Activity Extracellular Space Serine-type Endopeptidase Activity Cellular Response To UV-A Response To Amyloid-beta Response To UV-A Extracellular Region Peptidase Activity Proteolysis Cellular Response To UV Response To Light Stimulus Perineuronal Net Golgi Lumen Cellular Response To Light Stimulus Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein Metabolic Process Regulation Of Cell Migration Response To Radiation Central Nervous System Development Regulation Of Cell Motility Response To UV Regulation Of Locomotion Hyaluronic Acid Binding Cellular Response To Radiation Skeletal System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Ephrin Receptor Signaling Pathway Hydrolase Activity Cellular Response To Oxygen-containing Compound Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding	Leukocyte Migration Chemokine Activity Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Regulation Of T Cell Migration Antimicrobial Humoral Response Positive Regulation Of Mononuclear Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Mononuclear Cell Migration Inflammatory Response Extracellular Space Regulation Of Cell Migration Killing Of Cells Of Another Organism Cell Chemotaxis Cytokine Activity Regulation Of Cell Motility Granulocyte Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Mononuclear Cell Migration Heparin Binding Granulocyte Migration Humoral Immune Response Extracellular Region Leukocyte Tethering Or Rolling Cell Killing Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Adhesion CCR Chemokine Receptor Binding Chemotaxis Myeloid Leukocyte Migration Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Locomotion Chemokine Receptor Binding Regulation Of Leukocyte Cell-cell Adhesion Response To Cytokine Response To Peptide