ADHFE1 and LIPC

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ADHFE1	LIPC
Name		alcohol dehydrogenase iron containing 1	lipase C, hepatic type
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Metal Ion Binding Hydroxyacid-oxoacid Transhydrogenase Activity	Lipoprotein Lipase Activity Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Triacylglycerol Lipase Activity Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Carboxylic Ester Hydrolase Activity
	Biological Process	2-oxoglutarate Metabolic Process Lipid Metabolic Process L-glutamate Catabolic Process Via 2-hydroxyglutarate	Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis
Pathways		Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	Assembly of active LPL and LIPC lipase complexes Chylomicron clearance
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )	Advanced age-related macular degeneration ( 26691988 ) Age-related macular degeneration ( 20385826 21665990 23455636 ) Alanine aminotransferase levels ( 33547301 34315874 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Amyotrophic lateral sclerosis ( 18084291 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 34315874 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Cardiovascular disease risk factors ( 21943158 ) Change in serum metabolite levels ( 31636271 ) Change in serum metabolite levels (CMS) ( 31636271 ) Cholesterol efflux capacity ( 30369316 ) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766 ) Cognitive performance ( 20125193 ) Eosinophil count ( 32888494 ) Gout ( 22179738 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol ( 18193043 18193044 19060906 19060910 19060911 20686565 20864672 21347282 23505323 24097068 25961943 26160806 26582766 26780889 29404214 ) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549 32759990 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels in HIV infection ( 33109212 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) Hematocrit ( 32888494 ) Hematological and biochemical traits ( 20139978 ) Hemoglobin ( 32888494 ) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 31211820 33339817 33499410 ) Ischemic stroke ( 26089329 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Lipid metabolism phenotypes ( 19936222 22286219 ) Lipid traits ( 24023260 24386095 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 29403010 ) Lymphocyte count ( 32888494 ) Lysophosphatidylethanolamine levels ( 31551469 ) Metabolic syndrome ( 22399527 30382898 31589552 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Metabolite levels ( 19043545 22916037 23281178 23823483 ) Non-small cell lung cancer ( 23144319 ) Obesity-related traits ( 23251661 ) Phosphatidylethanolamine levels ( 31551469 ) Phospholipid levels (plasma) ( 22359512 ) Postprandial triglyceride response ( 32603185 ) Red blood cell count ( 32888494 ) Red blood cell traits ( 23222517 ) Schizophrenia ( 26198764 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite levels ( 31636271 33031748 ) Serum metabolite levels (CMS) ( 31636271 ) Stroke ( 26089329 ) Total cholesterol levels ( 28334899 29403010 29615537 33339817 ) Triglyceride levels ( 28334899 29403010 30698716 31087446 32203549 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels in HIV infection ( 33109212 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 18193043 20686565 24097068 25961943 26582766 30275531 ) Tumor necrosis factor levels ( 32805626 )
Interacting Genes		2 interacting genes: GNAQ LIPC	3 interacting genes: ADHFE1 APOB LRP1
Entrez ID		137872	3990
HPRD ID		12428	01058
Ensembl ID		ENSG00000147576	ENSG00000166035
Uniprot IDs		Q8IWW8	A6H8L5 P11150
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Response To Acidic PH Cellular Response To Acidic PH Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Response To PH G-protein Beta/gamma-subunit Complex Binding Detection Of Visible Light Entrainment Of Circadian Clock Phospholipase C-activating Serotonin Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Enzyme Regulator Activity Phototransduction, Visible Light Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Intermediate-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Triacylglycerol Lipase Activity Low-density Lipoprotein Particle Remodeling Lipase Activity Low-density Lipoprotein Particle Binding Triglyceride-rich Lipoprotein Particle Remodeling Triglyceride Catabolic Process Acylglycerol Catabolic Process Phospholipase Activity Phosphatidylcholine Catabolic Process Phospholipase A1 Activity Lipoprotein Lipase Activity Glycerophospholipid Catabolic Process High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Apolipoprotein Binding Phosphatidylcholine Lysophospholipase Activity Very-low-density Lipoprotein Particle Remodeling Reverse Cholesterol Transport Triglyceride-rich Lipoprotein Particle Clearance Plasma Lipoprotein Particle Clearance Postsynaptic Cytosol Heterotrimeric G-protein Complex Carboxylic Ester Hydrolase Activity Plasma Lipoprotein Particle Remodeling Response To PH Phototransduction Protein-containing Complex Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Phospholipid Catabolic Process Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction	Lipoprotein Transport Artery Morphogenesis Cellular Response To Amyloid-beta Response To Amyloid-beta Blood Vessel Morphogenesis Mature Chylomicron Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity L-glutamate Catabolic Process Via 2-hydroxyglutarate Hydroxyacid-oxoacid Transhydrogenase Activity Lipid Metabolic Process Chylomicron Remnant Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Triglyceride Mobilization Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Lysosomal Protein Catabolic Process Tube Morphogenesis Early Endosome Lipoprotein Biosynthetic Process Positive Regulation Of Cholesterol Storage Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis L-glutamate Catabolic Process Lipase Binding Clathrin Heavy Chain Binding Alcohol Dehydrogenase (NAD+) Activity Very-low-density Lipoprotein Particle Assembly Regulation Of Lysosomal Protein Catabolic Process Lipoprotein Catabolic Process Chylomicron Low-density Lipoprotein Particle Low-density Lipoprotein Particle Clearance Plasma Membrane Protein Complex Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Endocytic Vesicle Lumen Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding