CLDN3 and WNK4

Number of citations: 20 (PubMedID 15070779)
Data Source: HPRD (in vivo)

		CLDN3	WNK4
Name		claudin 3	WNK lysine deficient protein kinase 4
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction Anchoring Junction	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity
	Biological Process	Response To Hypoxia Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Cell Junction Assembly Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Maintenance Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Response To Gram-positive Bacterium Regulation Of Transepithelial Transport Negative Regulation Of Phosphate Transmembrane Transport	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Tight junction interactions	Stimuli-sensing channels
Diseases		None	Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Mean platelet volume ( 27863252 ) Platelet distribution width ( 27863252 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4	13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39
Entrez ID		1365	65266
HPRD ID		04219	03505
Ensembl ID		ENSG00000165215	ENSG00000126562
Uniprot IDs		O15551 Q75L79	Q96J92
PDB IDs		Not available	2V3S 4CH9 4CHB
GO Terms Enriched among Interactors		Regulation Of Bicellular Tight Junction Assembly Regulation Of Cell Junction Assembly Bicellular Tight Junction Maintenance Of Blood-brain Barrier Tight Junction Multicellular Organismal-level Homeostasis Homeostatic Process Positive Regulation Of Bicellular Tight Junction Assembly Cell Adhesion Establishment Of Endothelial Intestinal Barrier Cell-cell Junction Assembly Anchoring Junction Response To Lead Ion Cell Junction Organization Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Cell Junction Establishment Of Endothelial Barrier Endothelial Cell Development System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Vascular Permeability Cell Junction Assembly Bicellular Tight Junction Assembly Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Positive Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Cellular Component Maintenance Lateral Plasma Membrane Xenobiotic Transport Across Blood-nerve Barrier Aldosterone Secretion Regulation Of ATP Metabolic Process Membrane Regulation Of Cell Migration Cell Body	Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules