HUS1B and RAD1

Number of citations: 0 (PubMedID 11944979)
Data Source: HPRD (two hybrid, in vivo)

		HUS1B	RAD1
Name		HUS1 checkpoint clamp component B	RAD1 checkpoint DNA exonuclease
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex
	Molecular Function	None	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		None	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
GWAS		Aging ( 22773346 ) Metabolite levels ( 23823483 )	Daytime sleep phenotypes ( 27126917 )
Interacting Genes		4 interacting genes: HUS1 RAD1 RAD9A RAD9B	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		135458	5810
HPRD ID		13722	04400
Ensembl ID		ENSG00000188996	ENSG00000113456
Uniprot IDs		Q8NHY5	O60671
PDB IDs		Not available	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
GO Terms Enriched among Interactors		Checkpoint Clamp Complex Cellular Response To Ionizing Radiation DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Response To Radiation Regulation Of Cell Cycle Phase Transition Double-stranded DNA 3'-5' DNA Exonuclease Activity DNA Repair Meiotic Cell Cycle Checkpoint Signaling DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Nucleic Acid Metabolic Process Meiotic DNA Integrity Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Meiotic Recombination Checkpoint Signaling Response To Stress Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Replication Checkpoint Signaling Nucleoplasm 3'-5' Exonuclease Activity Signal Transduction Negative Regulation Of Meiotic Cell Cycle Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Substantia Nigra Development Exonuclease Activity Mitotic G2/M Transition Checkpoint Nucleotide-excision Repair Regulation Of Meiotic Cell Cycle Damaged DNA Binding Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Reproductive Process	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination