NCOA7 and AHR

Number of citations: 0 (PubMedID 10395741)
Data Source: BioGRID (pull down)

		NCOA7	AHR
Name		nuclear receptor coactivator 7	aryl hydrocarbon receptor
Structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Aryl Hydrocarbon Receptor Complex Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Response To Oxidative Stress	Blood Vessel Development Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance Cellular Response To Molecule Of Bacterial Origin Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		None	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		None	Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-monoxime Resveratrol Quercetin Tapinarof beta-Naphthoflavone Emodin 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Diosmin Kynurenic Acid Epigallocatechin gallate Cantharidin Indirubin Carbendazim Indigo
GWAS		Brain morphology (MOSTest) ( 32665545 ) Brugada syndrome ( 35210625 23872634 ) Endometrial cancer ( 27135401 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Left–right brain asymmetry ( 33723403 ) Menarche (age at onset) ( 25231870 ) Migraine ( 27322543 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 30578418 30224653 ) Urate levels ( 31578528 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Bitter beverage consumption ( 31046077 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Caffeine consumption ( 21490707 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Coffee consumption ( 31046077 25288136 21357676 29367735 31345160 31959922 ) Coffee consumption (cups per day) ( 25288136 31837886 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous squamous cell carcinoma ( 32041948 27424798 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels ( 32203549 ) Inflammatory bowel disease ( 26192919 ) Lung cancer in ever smokers ( 28604730 ) Metabolic traits ( 21886157 ) Microalbuminuria ( 31511532 ) Plasma kynurenine levels in major depressive disorder ( 29317604 ) Rosacea symptom severity ( 29771307 ) Severe influenza A (H1N1) infection ( 26379185 ) Sweet beverage consumption ( 31046077 ) Tea consumption ( 31046077 ) Triglyceride levels ( 32203549 ) Ulcerative colitis ( 26192919 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31630189 31511532 ) Urinary potassium excretion ( 31409800 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		4 interacting genes: AHR ARNT ESR1 ESR2	35 interacting genes: AIP AR ARNT ARNT2 BMAL1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 SRC STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		135112	196
HPRD ID		14814	02596
Ensembl ID		ENSG00000111912	ENSG00000106546
Uniprot IDs		B3KXK4 H0Y5F6 Q8NI08	P35869
PDB IDs		7OBP 8AR6 8AR9	5NJ8 7ZUB 8QMO
GO Terms Enriched among Interactors		Nuclear Receptor Activity Nuclear Aryl Hydrocarbon Receptor Complex Intracellular Receptor Signaling Pathway Nuclear Estrogen Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Estrogen Response Element Binding DNA-binding Transcription Factor Activity Maintenance Of Gastrointestinal Epithelium Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity TBP-class Protein Binding Transcription Regulator Complex Steroid Binding Epithelial Structure Maintenance Cellular Response To Estradiol Stimulus Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Digestive System Process Cellular Response To Lipid Sequence-specific DNA Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Receptor-mediated Signaling Pathway Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Response To Lipid Signal Transduction Protein Dimerization Activity Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Defense Response DNA Binding Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity	Aryl Hydrocarbon Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II General Transcription Initiation Factor Activity MRNA Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Nucleus Nucleic Acid Metabolic Process MRNA Transcription Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Transcription Factor TFIID Complex DNA-binding Transcription Factor Binding Chromatin DNA-templated Transcription Initiation Nuclear Receptor Binding RNA Metabolic Process DNA Binding Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Intracellular Receptor Signaling Pathway Aryl Hydrocarbon Receptor Complex Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coactivator Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II