COX8A and AMBP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		COX8A	AMBP
Name		cytochrome c oxidase subunit 8A	alpha-1-microglobulin/bikunin precursor
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Nuclear Membrane Extracellular Exosome Blood Microparticle Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Calcium Channel Inhibitor Activity IgA Binding Heme Binding Carbohydrate Binding Peptidase Inhibitor Activity Chondroitin Sulfate Binding Protein Homodimerization Activity Calcium Oxalate Binding Collagen Fibril Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport	Cell Adhesion Female Pregnancy Hemoglobin Metabolic Process Protein Catabolic Process Cellular Response To Reactive Oxygen Species Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response Cellular Oxidant Detoxification Cytochrome C Metabolic Process
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	Scavenging of heme from plasma
Drugs		Cholic Acid N-Formylmethionine	None
GWAS		Bipolar disorder ( 31043756 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: AMBP BATF EDDM3B MAGEA4 NPM1	12 interacting genes: A2M ALB COX8A DAAM1 ENO1 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3
Entrez ID		1351	259
HPRD ID		00468	01467
Ensembl ID		ENSG00000176340	ENSG00000106927
Uniprot IDs		P10176 Q53XN1	P02760
PDB IDs		5Z62 8D4T	1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD
GO Terms Enriched among Interactors		Myeloid Leukocyte Differentiation Myeloid Cell Differentiation T Cell Differentiation Involved In Immune Response Mononuclear Cell Differentiation Cytochrome C Metabolic Process T Cell Activation Involved In Immune Response Leukocyte Differentiation IgE Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Collagen Fibril Binding Calcium Oxalate Binding Cytochrome Metabolic Process Protein Homodimerization Activity IgA Binding Leukocyte Activation Involved In Immune Response Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Cell Activation Involved In Immune Response Serotonin Secretion By Platelet T Cell Differentiation Lymphocyte Activation Involved In Immune Response Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Regulation Of Endoribonuclease Activity T-helper 17 Cell Differentiation Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Matrix Side Of Mitochondrial Inner Membrane Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Apoptotic Process Regulation Of Adaptive Immune Response Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Negative Regulation Of Programmed Cell Death	Blood Microparticle Regulation Of Growth Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Insulin Receptor Signaling Pathway 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ATP Biosynthetic Process Endothelial Cell Migration Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ATP Biosynthetic Process Negative Regulation Of Anoikis Actin Cytoskeleton Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Binding Regulation Of Cell Growth Regulation Of Anoikis Actin Filament-based Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ATP Metabolic Process Biological Process Involved In Interaction With Symbiont Endodermal Cell Differentiation Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cytokine Production Involved In Inflammatory Response Phosphotyrosine Residue Binding Phosphatidylinositol Phosphate Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Growth Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Activation Platelet Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Endoplasmic Reticulum Lumen