CCDC127 and RNF11

Number of citations: 54 (PubMedID 15231748)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CCDC127	RNF11
Name		coiled-coil domain containing 127	ring finger protein 11
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	None	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Homeostasis	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
GWAS		No GWAS studies recorded	Atrial fibrillation ( 29290336 ) Male-pattern baldness ( 28196072 ) QRS duration ( 21076409 )
Interacting Genes		1 interacting genes: RNF11	69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		133957	26994
HPRD ID		14053	09955
Ensembl ID		ENSG00000164366	ENSG00000123091
Uniprot IDs		Q96BQ5	Q9Y3C5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome