COX6A2 and SNX21

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		COX6A2	SNX21
Name		cytochrome c oxidase subunit 6A2	sorting nexin family member 21
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex IV	Endosome Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Oxidoreductase Activity Enzyme Regulator Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen	Protein Transport
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	None
Drugs		Cholic Acid N-Formylmethionine	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		5 interacting genes: APP COL6A2 MRPL12 POT1 SNX21	4 interacting genes: APP COX6A2 HSF2BP LRRK1
Entrez ID		1339	90203
HPRD ID		03598	16641
Ensembl ID		ENSG00000156885	ENSG00000124104
Uniprot IDs		Q02221	A0A0S2Z632 Q05DJ0 Q8WY78 Q969T3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Collagen Type VI Trimer Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomere Assembly Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Shelterin Complex Axon Choice Point Recognition Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Heparan Sulfate Binding Signaling Receptor Activator Activity Mitochondrial Transcription DEAD/H-box RNA Helicase Binding	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Canonical Wnt Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Female Meiosis I Osteoclast Development Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Wnt Signaling Pathway Peptidase Activator Activity Cellular Response To Manganese Ion Double-strand Break Repair Involved In Meiotic Recombination Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding