COX6A2 and COL6A2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		COX6A2	COL6A2
Name		cytochrome c oxidase subunit 6A2	collagen type VI alpha 2 chain
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex IV	Extracellular Region Collagen Trimer Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Oxidoreductase Activity Enzyme Regulator Activity	Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen	Cell Adhesion Response To UV Response To Glucose Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Apoptotic Process
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Cholic Acid N-Formylmethionine	None
Diseases		None	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Central corneal thickness ( 29760442 32528159 ) Height ( 31562340 ) Intraocular pressure ( 29235454 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		5 interacting genes: APP COL6A2 MRPL12 POT1 SNX21	5 interacting genes: ABCD3 COX6A2 FN1 SIRPA SLC38A3
Entrez ID		1339	1292
HPRD ID		03598	02110
Ensembl ID		ENSG00000156885	ENSG00000142173
Uniprot IDs		Q02221	A0A384MDP3 P12110
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Collagen Type VI Trimer Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomere Assembly Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Shelterin Complex Axon Choice Point Recognition Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Heparan Sulfate Binding Signaling Receptor Activator Activity Mitochondrial Transcription DEAD/H-box RNA Helicase Binding	Regulation Of Extracellular Matrix Organization Positive Regulation Of Cell Adhesion Core-binding Factor Complex Tissue Regeneration Collagen Binding Collagen Type VI Trimer Basement Membrane Endodermal Cell Differentiation Multicellular Organismal Locomotion Response To Polyamine Macromolecule Response To Activity Response To Muscle Activity Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Phytanic Acid Metabolic Process Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Cellular Response To Potassium Ion Starvation Asparagine Transport Asparagine Transmembrane Transport Positive Regulation Of Glutamine Transport Glutamine Secretion L-asparagine, Sodium:proton Antiporter Activity L-asparagine Transmembrane Transporter Activity Histidine Transport L-histidine Import Across Plasma Membrane L-glutamine, Sodium:proton Antiporter Activity L-asparagine Import Across Plasma Membrane L-histidine, Sodium:proton Antiporter Activity Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Cellular Response To Interleukin-12 Cardiac Muscle Tissue Regeneration Ossification Regeneration Calcium-independent Cell-matrix Adhesion Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome L-histidine Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Neutral L-amino Acid:sodium Symporter Activity L-glutamine Import Across Plasma Membrane L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Monocyte Extravasation Response To Reactive Oxygen Species Regulation Of Cell Activation Response To Bleomycin Apoptotic Nuclear Changes