CORT and SSTR4

Number of citations: 0 (PubMedID 9125122)
Data Source: BioGRID (unspecified method), HPRD (in vivo)

		CORT	SSTR4
Name		cortistatin	somatostatin receptor 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse	Plasma Membrane Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Cell Migration	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		None	Somatostatin Lutetium Lu 177 dotatate
GWAS		Male-pattern baldness ( 28196072 )	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood sugar levels ( 29403010 ) Hypothyroidism ( 27182965 ) Mitochondrial DNA copy number ( 30704525 ) Obesity-related traits ( 23251661 ) Vitamin D levels ( 26704534 )
Interacting Genes		7 interacting genes: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	2 interacting genes: CORT SST
Entrez ID		1325	6754
HPRD ID		04150	01676
Ensembl ID		ENSG00000241563	ENSG00000132671
Uniprot IDs		O00230 Q8IUV6	P31391
PDB IDs		7S8L 7S8M 7VDL 7VV4 8X8L	7XMS 7XMT
GO Terms Enriched among Interactors		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuron Projection Response To Glucocorticoid Response To Corticosteroid Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation Response To Lipid Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Response To Hormone Signal Transduction Plasma Membrane Cellular Response To Estradiol Stimulus Positive Regulation Of Cytokinesis Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Mast Cell Secretagogue Receptor Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Membrane Regulation Of Insulin Secretion Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Hormone-mediated Apoptotic Signaling Pathway Regulation Of Cell Division Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process	Receptor Ligand Activity Hormone Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Somatostatin Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Signaling Cell-cell Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Regulation Of Cell Motility Regulation Of Cell Migration Digestion Neuronal Dense Core Vesicle Response To Acidic PH Hyperosmotic Response Regulation Of Locomotion Response To PH Extracellular Space G Protein-coupled Receptor Binding Response To Osmotic Stress Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway GABA-ergic Synapse Response To Amino Acid Extracellular Region Response To Nutrient Hormone-mediated Signaling Pathway Response To Steroid Hormone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway