TMEM182 and SYNE4

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		TMEM182	SYNE4
Name		transmembrane protein 182	spectrin repeat containing nuclear envelope family member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Muscle Organ Development Myotube Cell Development Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Myoblast Differentiation Negative Regulation Of Myoblast Fusion	Establishment Of Epithelial Cell Apical/basal Polarity
GWAS		Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Blood pressure ( 24903457 ) Blood pressure (anthropometric measures interaction) ( 24903457 ) Chromium levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophilic esophagitis ( 34506852 ) General risk tolerance (MTAG) ( 30643258 ) Night sleep phenotypes ( 27126917 ) Number of sexual partners ( 30643258 ) Photic sneeze reflex ( 27182965 ) PR interval ( 30046033 32439900 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking initiation ( 30617275 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (current vs never) ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Sun-seeking behavior ( 32920024 )	No GWAS studies recorded
Interacting Genes		15 interacting genes: CLDN5 FNDC9 GJA8 GPR42 KLRC1 MALL MS4A3 PLP1 SMIM3 SUSD3 SYNE4 TMEM140 TMEM218 TMEM31 TSPAN12	56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648
Entrez ID		130827	163183
HPRD ID		08698	08776
Ensembl ID		ENSG00000170417	ENSG00000181392
Uniprot IDs		A0A494C0U9 B8ZZ71 Q6ZP80	Q8N205
PDB IDs		Not available	6R16 6WMD
GO Terms Enriched among Interactors		Membrane Myelination Axon Ensheathment Structural Constituent Of Myelin Sheath Maintenance Of Blood-brain Barrier Inhibitory MHC Class Ib Receptor Activity	Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity