COL17A1 and ITGA6

Number of citations: 0 (PubMedID 11739652)
Data Source: HPRD (two hybrid, in vivo)

		COL17A1	ITGA6
Name		collagen type XVII alpha 1 chain	integrin subunit alpha 6
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha6-beta1 Complex Integrin Alpha6-beta4 Complex
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly	Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Migration Cell-substrate Adhesion Nail Development Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Cardiac hypertrophy ( 21348951 )	Alzheimer's disease biomarkers ( 23419831 ) Diabetic kidney disease ( 26305897 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Food allergy ( 29030101 ) Metabolite levels ( 23823483 ) Peanut allergy ( 29030101 ) Prostate cancer ( 19767753 31562322 )
Interacting Genes		18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN	23 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4 USP40
Entrez ID		1308	3655
HPRD ID		00223	00945
Ensembl ID		ENSG00000065618	ENSG00000091409
Uniprot IDs		Q9UMD9	A0A8C8KBL6 A0AAQ5BID9 P23229
PDB IDs		8IZS	7CEB 7CEC
GO Terms Enriched among Interactors		Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction	Cell Adhesion Integrin Binding Cell-substrate Adhesion Hemidesmosome Assembly Hemidesmosome Cell-matrix Adhesion Extracellular Exosome Focal Adhesion Cell Migration Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Endocytosis Plasma Membrane Laminin Binding Membrane Cell Motility Positive Regulation Of Transport Regulation Of Superoxide Metabolic Process Cell Adhesion Mediated By Integrin Vesicle-mediated Transport Low-density Lipoprotein Particle Mediated Signaling Import Into Cell Cell Surface Cell-substrate Junction Assembly Cell-substrate Junction Organization Regulation Of Spontaneous Synaptic Transmission Presynaptic Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Action Potential Cellular Response To Hydroperoxide Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Leukocyte Activation Receptor-mediated Endocytosis Vesicle Regulation Of Transport Receptor Internalization Receptor Complex Regulation Of Supramolecular Fiber Organization Insulin Receptor Substrate Binding Cell-cell Junction Response To Manganese Ion Anchoring Junction Cell Activation Mesodermal Cell Differentiation Endothelial Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Biological Quality