COL9A1 and COMP

Number of citations: 0 (PubMedID 15047691)
Data Source: HPRD (in vitro)

		COL9A1	COMP
Name		collagen type IX alpha 1 chain	cartilage oligomeric matrix protein
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IX Trimer Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Animal Organ Morphogenesis	Skeletal System Development Ossification Chondrocyte Development Endochondral Bone Growth Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Cell Adhesion Blood Coagulation Protein Secretion Animal Organ Morphogenesis Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Cartilage Development Protein Homooligomerization Muscle Cell Development Limb Development Bone Morphogenesis Platelet Aggregation Cellular Senescence Vascular Associated Smooth Muscle Cell Development Bone Growth Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation Cartilage Homeostasis
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Integrin cell surface interactions ECM proteoglycans
Drugs		None	Calcium
Diseases		None	Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		No GWAS studies recorded	Osteoarthritis (with total hip replacement) ( 28319091 ) Osteoarthritis biomarkers ( 25057126 ) QT interval ( 29213071 )
Interacting Genes		4 interacting genes: CFTR COMP FN1 MAG	10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB
Entrez ID		1297	1311
HPRD ID		00367	02632
Ensembl ID		ENSG00000112280	ENSG00000105664
Uniprot IDs		A0A804HIB6 P20849	P49747
PDB IDs		2UUR 5CTD 5CTI 5CVA 5CVB	3FBY
GO Terms Enriched among Interactors		Proteoglycan Binding Vesicle Docking Involved In Exocytosis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Multicellular Organismal Process Vesicle Docking Collagen Binding Regulation Of Cell Growth Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Organelle Localization By Membrane Tethering Regulation Of Axon Extension Membrane Docking Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protease Binding Regulation Of Growth Extracellular Matrix Structural Constituent Regulation Of Nervous System Process Positive Regulation Of Anion Channel Activity Mesaxon Positive Regulation Of Monoatomic Anion Transport Heparin Binding Integrin Binding Positive Regulation Of Cell Growth Negative Regulation Of Monocyte Activation Regulation Of Axonogenesis Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Ganglioside GT1b Binding Positive Regulation Of Developmental Growth Regulation Of Exocytosis Positive Regulation Of Enamel Mineralization Anatomical Structure Formation Involved In Morphogenesis Cell Adhesion Tendon Development Cartilage Homeostasis Calcium-independent Cell-matrix Adhesion Regulation Of Anatomical Structure Morphogenesis Compact Myelin Nervous System Process Transepithelial Water Transport Response To Wounding Myelin Sheath Adaxonal Region Acrosomal Vesicle Exocytosis Positive Regulation Of Tooth Mineralization Cellular Component Assembly Positive Regulation Of Neurogenesis Neural Crest Cell Migration Involved In Autonomic Nervous System Development Central Nervous System Myelin Formation	Epithelium Development Proteoglycan Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Tissue Development Positive Regulation Of Fibroblast Proliferation Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Metallochaperone Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Inner Ear Morphogenesis Endoplasmic Reticulum Lumen Biological Process Involved In Interaction With Symbiont Diencephalon Morphogenesis Wound Healing Collagen Trimer Metanephric Glomerulus Vasculature Development Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Regulation Of Fibroblast Proliferation Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Corticotropin Secretion Copper-dependent Protein Binding Copper Ion Export Collagen Type II Trimer Roof Of Mouth Development Extracellular Matrix Basement Membrane Collagen Type IX Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Metencephalon Development TRC Complex Identical Protein Binding Extracellular Matrix Structural Constituent Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport Lipid Digestion Copper Chaperone Activity Calcium-independent Cell-matrix Adhesion Nitric Oxide Transport Carbon Dioxide Transmembrane Transporter Activity Water Transmembrane Transporter Activity Animal Organ Morphogenesis Ameboidal-type Cell Migration Transepithelial Water Transport Carbon Dioxide Transmembrane Transport