COL5A1 and BMP1

Number of citations: 0 (PubMedID 11741999)
Data Source: HPRD (in vivo)

		COL5A1	BMP1
Name		collagen type V alpha 1 chain	bone morphogenetic protein 1
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Golgi Apparatus Vesicle
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)	None
GWAS		Blood pressure ( 24954895 ) Central corneal thickness ( 20719862 22814818 23493294 32528159 28171582 31798171 29760442 30894546 ) Corneal structure ( 23291589 ) Crohn's disease (need for surgery) ( 23665963 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Longevity ( 20834067 ) Metabolite levels ( 23823483 ) Phosphatidylcholine levels ( 31551469 ) Refractive error ( 32231278 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Coronary artery disease ( 29212778 ) Hypertriglyceridemia ( 23505323 ) Myocardial infarction ( 33532862 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )
Interacting Genes		10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		1289	649
HPRD ID		00368	00209
Ensembl ID		ENSG00000130635	ENSG00000168487
Uniprot IDs		B2ZZ86 P20908 Q59EE7	P13497
PDB IDs		7Y37	3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
GO Terms Enriched among Interactors		Extracellular Matrix Collagen Binding Platelet Alpha Granule Lumen Golgi Lumen Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Extracellular Matrix Binding Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Region Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Platelet-derived Growth Factor Binding Cell Surface Regulation Of Glomerular Mesangial Cell Proliferation Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Autophosphorylation Proteoglycan Binding Platelet-derived Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Positive Regulation Of Endothelial Cell Migration Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Platelet Alpha Granule Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Anatomical Structure Morphogenesis Regulation Of Endothelial Cell Proliferation Growth Factor Activity Regulation Of Developmental Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Regulation Of Response To Wounding Regulation Of Cell Motility Regulation Of Locomotion Response To Wounding Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phospholipid Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination